Abstract
This study demonstrates a biological route to programming well-defined protein-inorganic interfaces with an arrayed geometry via modular peptide tag technology. To illustrate this concept, we designed a model multifunctional fusion protein, which simultaneously displays a maltose-binding protein (MBP), a green fluorescence protein (GFPuv) and an inorganic-binding peptide (AgBP2C). The fused combinatorially selected AgBP2C tag controls and site-directs the multifunctional fusion protein to immobilize on silver nanoparticle arrays that are fabricated on specific domain surfaces of ferroelectric LiNbO 3 via photochemical deposition and in situ synthesis. Our combined peptide-assisted biological and ferroelectric lithography approach offers modular design and versatility in tailoring surface reactivity for fabrication of nanoscale devices in environmentally benign conditions.
Original language | English |
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Pages (from-to) | 1865-1871 |
Number of pages | 7 |
Journal | ACS applied materials & interfaces |
Volume | 4 |
Issue number | 4 |
DOIs | |
Publication status | Published - 25 Apr 2012 |
Keywords
- biological-material interface
- ferroelectric LiNbO substrate
- heterofunctional proteins
- hierarchical assemblies
- photochemical deposition
- protein microarrays