TY - JOUR
T1 - Modification of polysulfones by click chemistry
T2 - Amphiphilic graft copolymers and their protein adsorption and cell adhesion properties
AU - Yilmaz, Gorkem
AU - Toiserkani, Hojjat
AU - Demirkol, Dilek Odaci
AU - Sakarya, Serhan
AU - Timur, Suna
AU - Yagci, Yusuf
AU - Torun, Lokman
PY - 2011/1/1
Y1 - 2011/1/1
N2 - Well-defined amphiphilic graft copolymer with hydrophobic polysulfone (PSU) backbone and hydrophilic poly(acrylic acid) (PAA) side chains were synthesized and characterized. For this purpose, commercially available PSU was converted to azido-functionalized polymer (PSU-N3) by successive chloromethylation and azidation processes. Independently, poly(tert-butyl acrylate) (PtBA) with an alkyne-end-group is obtained by using suitable initiator in atom transfer radical polymerization (ATRP). Then, this polymer was successfully grafted onto PSU-N3 by click chemistry to yield polysulfone-graft-poly(tert-butyl acrylate), (PSU-g-PtBA). Finally, amphiphilic polysulfone-graft-poly(acrylic acid), (PSU-g-PAA), membranes were obtained by hydrolyzing precursor the PSU-g-PtBA membranes in trifluoroacetic acid. The final polymer and intermediates at various stages were characterized by 1H NMR, FTIR, GPC, and SEM analyses. Protein adsorption and eukaryotic and prokaryotic cell adhesion on PSU-g-PAA were studied and compared to those of PSU-g-PtBA and unmodified PSU.
AB - Well-defined amphiphilic graft copolymer with hydrophobic polysulfone (PSU) backbone and hydrophilic poly(acrylic acid) (PAA) side chains were synthesized and characterized. For this purpose, commercially available PSU was converted to azido-functionalized polymer (PSU-N3) by successive chloromethylation and azidation processes. Independently, poly(tert-butyl acrylate) (PtBA) with an alkyne-end-group is obtained by using suitable initiator in atom transfer radical polymerization (ATRP). Then, this polymer was successfully grafted onto PSU-N3 by click chemistry to yield polysulfone-graft-poly(tert-butyl acrylate), (PSU-g-PtBA). Finally, amphiphilic polysulfone-graft-poly(acrylic acid), (PSU-g-PAA), membranes were obtained by hydrolyzing precursor the PSU-g-PtBA membranes in trifluoroacetic acid. The final polymer and intermediates at various stages were characterized by 1H NMR, FTIR, GPC, and SEM analyses. Protein adsorption and eukaryotic and prokaryotic cell adhesion on PSU-g-PAA were studied and compared to those of PSU-g-PtBA and unmodified PSU.
KW - amphiphilic polymers
KW - click chemistry
KW - functionalization of polymers
KW - graft copolymers
KW - poly(ether sulfones)
UR - http://www.scopus.com/inward/record.url?scp=78649854271&partnerID=8YFLogxK
U2 - 10.1002/pola.24424
DO - 10.1002/pola.24424
M3 - Article
AN - SCOPUS:78649854271
SN - 0887-624X
VL - 49
SP - 110
EP - 117
JO - Journal of Polymer Science, Part A: Polymer Chemistry
JF - Journal of Polymer Science, Part A: Polymer Chemistry
IS - 1
ER -