Magnetic Nanoparticles Based Solid Phase Extraction Methods for the Determination of Trace Elements

Elif Öztürk Er, Gamze Dalgıç Bozyiğit, Çağdaş Büyükpınar, Sezgin Bakırdere*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

51 Citations (Scopus)


The past three decades has seen significant advancements in instrumental detection techniques for both organic and inorganic analytes, leading to more accurate and precise measurements. The relevance of sample preparation prior to instrumental reading cannot be underestimated, and this area has also seen major improvements, with solid phase extraction (SPE) and its miniaturized version (solid phase microextraction, SPME) serving as an efficient clean-up and preconcentration method for analytes. Magnetic nanoparticles (MNPs) belong to the new generation of sorbents, and their characteristic small size and easy manipulation under magnetic field make them ideal materials for extraction of several analytes. This review presents the basic principles of SPE and SPME, and lays more emphasis on different types of MNPs that have been used as efficient separation and preconcentration tools. In addition, application of MNPs for the determination of trace elements in environmental, biological and food samples are well documented in this review.

Original languageEnglish
Pages (from-to)231-249
Number of pages19
JournalCritical Reviews in Analytical Chemistry
Issue number2
Publication statusPublished - 2022
Externally publishedYes

Bibliographical note

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© 2020 Taylor & Francis Group, LLC.


  • Magnetic nanoparticles (MNPs)
  • solid phase extraction (SPE)
  • solid phase microextraction (SPME)
  • trace elements


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