Macroporous Surgical Mesh from a Natural Cocoon Composite

Yong Ming Chen; Lian Sheng Zang; Behlul Koc-Bilican; Ismail Bilican; Chris Holland; Demet Cansaran-Duman; Tugce Karaduman; Arzu Çolak; Yasin Bayır; Zekai Halici; Sevilay Ozmen; Asad Ali; Jalel Labidi; Caglar Elbuken; Murat Kaya

doi:10.1021/acssuschemeng.1c06941

Macroporous Surgical Mesh from a Natural Cocoon Composite

Yong Ming Chen, Lian Sheng Zang^*, Behlul Koc-Bilican, Ismail Bilican, Chris Holland, Demet Cansaran-Duman, Tugce Karaduman, Arzu Çolak, Yasin Bayır, Zekai Halici, Sevilay Ozmen, Asad Ali, Jalel Labidi, Caglar Elbuken, Murat Kaya^*

^*Corresponding author for this work

Department of Molecular Biology and Genetics

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Recently, traditional polymer-based surgical meshes have drawn unwanted attention as a result of host tissue complications arising from infection, biocompatibility, and mechanical compatibility. Seeking an alternative solution, we present a hierarchically structured nanofibrous surgical mesh derived from the naturally woven cocoon of the Japanese giant silkworm, termed MothMesh. We report that it displays nontoxicity, biocompatibility, suitable mechanical properties, and porosity while showing no adverse effect in animal trials and even appears to enhance cell proliferation. Hence, we assert that the use of this natural material may provide an effective and improved alternative to existing synthetic meshes.

Original language	English
Pages (from-to)	5728-5738
Number of pages	11
Journal	ACS Sustainable Chemistry and Engineering
Volume	10
Issue number	18
DOIs	https://doi.org/10.1021/acssuschemeng.1c06941
Publication status	Published - 9 May 2022

Bibliographical note

Publisher Copyright:
© 2022 American Chemical Society. All rights reserved.

Funding

This study was funded by the Program of Introducing Talents to Chinese Universities (111 Program, D20023). The authors thanks the ASUBTAM (Aksaray University) for providing laboratory facilities and access to equipment.

Funders	Funder number
Program of Introducing Talents to Chinese Universities
Higher Education Discipline Innovation Project	D20023

Keywords

biocompatibility
fibroin
sericin
surgical mesh
sustainable material
tissue engineering

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10.1021/acssuschemeng.1c06941

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Chen, Y. M., Zang, L. S., Koc-Bilican, B., Bilican, I., Holland, C., Cansaran-Duman, D., Karaduman, T., Çolak, A., Bayır, Y., Halici, Z., Ozmen, S., Ali, A., Labidi, J., Elbuken, C., & Kaya, M. (2022). Macroporous Surgical Mesh from a Natural Cocoon Composite. ACS Sustainable Chemistry and Engineering, 10(18), 5728-5738. https://doi.org/10.1021/acssuschemeng.1c06941

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title = "Macroporous Surgical Mesh from a Natural Cocoon Composite",

abstract = "Recently, traditional polymer-based surgical meshes have drawn unwanted attention as a result of host tissue complications arising from infection, biocompatibility, and mechanical compatibility. Seeking an alternative solution, we present a hierarchically structured nanofibrous surgical mesh derived from the naturally woven cocoon of the Japanese giant silkworm, termed MothMesh. We report that it displays nontoxicity, biocompatibility, suitable mechanical properties, and porosity while showing no adverse effect in animal trials and even appears to enhance cell proliferation. Hence, we assert that the use of this natural material may provide an effective and improved alternative to existing synthetic meshes.",

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AU - Koc-Bilican, Behlul

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AU - Holland, Chris

AU - Cansaran-Duman, Demet

AU - Karaduman, Tugce

AU - Çolak, Arzu

AU - Bayır, Yasin

AU - Halici, Zekai

AU - Ozmen, Sevilay

AU - Ali, Asad

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AU - Elbuken, Caglar

AU - Kaya, Murat

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AB - Recently, traditional polymer-based surgical meshes have drawn unwanted attention as a result of host tissue complications arising from infection, biocompatibility, and mechanical compatibility. Seeking an alternative solution, we present a hierarchically structured nanofibrous surgical mesh derived from the naturally woven cocoon of the Japanese giant silkworm, termed MothMesh. We report that it displays nontoxicity, biocompatibility, suitable mechanical properties, and porosity while showing no adverse effect in animal trials and even appears to enhance cell proliferation. Hence, we assert that the use of this natural material may provide an effective and improved alternative to existing synthetic meshes.

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Macroporous Surgical Mesh from a Natural Cocoon Composite

Abstract

Bibliographical note

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Keywords

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