Low-methoxyl pectin–zeolite hydrogels controlling drug release promote in vitro wound healing

Banu Kocaaga, Ozge Kurkcuoglu*, Melkon Tatlier, Saime Batirel, F. Seniha Guner

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

49 Citations (Scopus)

Abstract

This study presents the design of novel hydrogel films, based on low-methoxyl (LM) pectin and NaA- or ZnA-zeolite particles, to serve as wound dressing materials with controlled drug delivery properties. We studied the effects of the preparation method of hydrogels, the amounts of crosslinker, drug and zeolite, and the type of cation in zeolites on the drug release mechanisms from the hydrogels. Ionic strengths of both film and external medium dictated the drug release behavior of the films, while the other parameters also played essential roles. NaA-zeolite hydrogels prepared using membrane diffusion controlled system, could reach a drug release ratio of 86% within 5 h. The drug-free hydrogels displayed no cytotoxicity while supporting cell proliferation and migration. Our cost-effective LM pectin–zeolite hydrogels promise to be effective wound dressing materials with controlled drug delivery ability, transparency, good swelling properties, ability to hold fluids, good oxygen transmission rate, and biocompatibility.

Original languageEnglish
Article number47640
JournalJournal of Applied Polymer Science
Volume136
Issue number24
DOIs
Publication statusPublished - 20 Jun 2019

Bibliographical note

Publisher Copyright:
© 2019 Wiley Periodicals, Inc.

Funding

The authors sincerely thank Herbstrith & Fox Company (Germany) for providing LM pectin. This work was funded by The Scientific and Technological Research Council of Turkey (TUBITAK) with project number of 115M439.

FundersFunder number
TUBITAK115M439
Türkiye Bilimsel ve Teknolojik Araştirma Kurumu

    Keywords

    • biomedical applications
    • biopolymers and renewable polymers
    • drug delivery systems

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