Lipase mediated synthesis of polycaprolactone and its silica nanohybrid

Meltem Akkulak, Yasemin Kaptan, Yasar Andelib Aydin*, Yuksel Avcibasi Guvenilir

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


In this study, rice husk ash (RHA) silanized with 3-glycidyloxypropyl trimethoxysilane was used as support material to immobilize Candida antarctica lipase B. The developed biocatalyst was then utilized in the ring opening polymerization (ROP) of ϵ-caprolactone and in situ development of PCL/Silica nanohybrid. The silanization degree of RHA was determined as 4 % (w) by thermal gravimetric analysis (TGA). Structural investigations and calculation of molecular weights of nanohybrids were realized by proton nuclear magnetic resonance (1H NMR). Crystallinity was determined by differential scanning calorimetry (DSC) and X-ray diffraction (XRD). Scanning Electron Microscopy (SEM) was used for morphological observations. Accordingly, the PCL composition in the nanohybrid was determined as 4 %, approximately. Short chained amorphous PCL was synthesized with a number average molecular weight of 4400 g/mol and crystallinity degree of 23 %. In regards to these properties, synthesized PCL/RHA composite can find use biomedical applications.

Original languageEnglish
Pages (from-to)957-965
Number of pages9
JournalPure and Applied Chemistry
Issue number6
Publication statusPublished - 1 Jun 2019

Bibliographical note

Publisher Copyright:
© 2019 IUPAC and De Gruyter.


  • 3-glycidyloxypropyl trimethoxysilane
  • Candida antarctica lipase B
  • POC-17
  • polycaprolactone
  • rice husk ash


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