Layer-by-layer self-assembled emerging systems for nanosized drug delivery

Nejla Cini*, Ferah Calisir

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)


New frontiers in the development of stimuli-responsive surfaces that offer switchable properties according to the end-use application have added a new dimension to the design of drug-delivery systems (DDS). In this respect, layer-by-layer (LbL) self-assembled technologies have attracted interest in nano-DDS (NDDS) design due to the advantage of encapsulating different drug types either individually or in multiple formulations as an easy-to-apply and cost-effective strategy. LbL-based microcapsules and core-shell structures in the form of polyelectrolyte multilayers (PEMs) have been proposed as versatile vehicles for NDDS over the last quarter. This review aims to provide a global view of LbL-PEMs used as templates in NDDS for the last 5 years with an emphasis on emerging drug loading and release strategies.

Original languageEnglish
Pages (from-to)1961-1980
Number of pages20
Issue number25
Publication statusPublished - 1 Oct 2022

Bibliographical note

Publisher Copyright:
© 2023 Future Medicine Ltd.


  • drug delivery
  • drug loading
  • drug release
  • layer-by-layer deposition
  • LbL deposition
  • nanodrug delivery
  • nanomedicine
  • PEM
  • polyelectrolyte multilayers


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