Kinetic and microbial response of activated sludge community to acute and chronic exposure to tetracycline

Ilke Pala-Ozkok*, Emine Ubay-Cokgor, Daniel Jonas, Derin Orhon

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

Current study aimed to discover both kinetic and microbial response of activated sludge biomass to continuous exposure to tetracycline, one of the most frequently detected antibiotics in wastewaters. Respirometric analysis and model evaluation of the oxygen utilization rate profiles generated at critical phases of the experimental period showed that, continuous exposure to tetracycline caused complete suppression of substrate storage aside from mild inhibition on the growth kinetics and it exerted a significant binding action with available organic carbon, leading to less oxygen consumption. Additionally, increase in endogenous decay rates by 1.5 fold was associated with maintenance energy dictated by the presence and production of antibiotic resistance genes, as demonstrated by resistance gene profile. High-throughput sequencing results showed that continuously exposure to tetracycline caused a significant shift in the community structure at species level so that tetracycline resistant bacteria like Arthrobacter sp and Diaphorobacter sp dominated the bacterial community.

Original languageEnglish
Pages (from-to)418-426
Number of pages9
JournalJournal of Hazardous Materials
Volume367
DOIs
Publication statusPublished - 5 Apr 2019

Bibliographical note

Publisher Copyright:
© 2018 Elsevier B.V.

Funding

This study was supported by Turkish Academy of Sciences as part of Fellowship Program for Integrated Doctoral Studies . Authors thank The Scientific Research Fund of Istanbul Technical University (ProjectNr:33680 and ProjectNr:33742) and The Scientific and Technological Research Council of Turkey . Authors thank University of Kiel Institute of Clinical Molecular Biology for their technical assistance.

FundersFunder number
Türkiye Bilimsel ve Teknolojik Araştirma Kurumu
Türkiye Bilimler Akademisi
Istanbul Teknik Üniversitesi

    Keywords

    • Activated sludge modeling
    • Aerobic processes
    • Chronic inhibition
    • High-throughput sequencing
    • Tetracycline

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