Investigation of vehicle-induced whole-body vibration with experimental rat models

Ayse Nur Hazar-Yavuz*, Akif Yavuz

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


This comprehensive study delves into the profound impact of low frequency whole-body vibrations (WBV) on health, focusing on the utilization of rat models for understanding this complex phenomenon. It highlights the adverse effects of low frequency vehicle vibrations on human health, encompassing musculoskeletal discomfort, fatigue, concentration deficits, potential gastrointestinal issues, hearing impairment, and psychological stress. WBV's influence extends to physiological and cognitive consequences, affecting multiple systems. Prolonged WBV exposure, particularly in the lumbar region, is associated with spinal disorders. To navigate ethical challenges in studying WBV in humans, rat models are crucial tools. These models, with customized parameters, offer insights into various health aspects, including bone density, muscle strength, hormonal responses, cardiovascular parameters, and more. Advantages and disadvantages of using low-frequency vibrations in rat models are discussed. While demonstrating WBV's potential effect in research, further exploration is essential to optimize parameters and applications, always prioritizing ethical considerations and regulations. The article concludes by proposing measures to mitigate vehicle vibration impacts on drivers, emphasizing the collaboration of manufacturers, drivers, and regulators for safer and healthier driving experiences.

Original languageEnglish
Pages (from-to)2310-2329
Number of pages20
JournalJournal of Research in Pharmacy
Issue number6
Publication statusPublished - 2023

Bibliographical note

Publisher Copyright:
© 2023 Marmara University Press.


  • WBV
  • Whole-body vibration
  • low-frequency vibration
  • rat experiments
  • vehicle vibrations


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