Investigation of the biological properties of water soluble quinoline substituted phthalocyanines

Didem Evren; Ibrahim Özçeşmeci; B. Şebnem Sesalan; Ayfer Kalkan Burat

doi:10.1016/j.synthmet.2013.02.015

Investigation of the biological properties of water soluble quinoline substituted phthalocyanines

Didem Evren, Ibrahim Özçeşmeci, B. Şebnem Sesalan^*, Ayfer Kalkan Burat

^*Corresponding author for this work

Department of Chemistry

Istanbul Technical University

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

The interaction between water soluble quinoline substituted phthalocyanines (Pcs) 1Q and 2Q and BSA (bovine serum albumin) was investigated. The binding modes of 1Q and 2Q to BSA was investigated by UV-vis and fluorescence titration experiments. The quenching effect of Pcs 1Q and 2Q on the fluorescence of Acridine Orange (AO)-BSA complex was determined. The results indicated that these water soluble phthalocyanines (Pcs) can bind to BSA and can be transported in circulatory system. Water soluble nature of both Pcs enhances cellular uptake and these dyes can be used in photodynamic theraphy (PDT).

Original language	English
Pages (from-to)	31-35
Number of pages	5
Journal	Synthetic Metals
Volume	168
Issue number	1
DOIs	https://doi.org/10.1016/j.synthmet.2013.02.015
Publication status	Published - 2013

Keywords

Acridineorange
BSA
Fluorescence
Phthalocyanine

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10.1016/j.synthmet.2013.02.015

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title = "Investigation of the biological properties of water soluble quinoline substituted phthalocyanines",

abstract = "The interaction between water soluble quinoline substituted phthalocyanines (Pcs) 1Q and 2Q and BSA (bovine serum albumin) was investigated. The binding modes of 1Q and 2Q to BSA was investigated by UV-vis and fluorescence titration experiments. The quenching effect of Pcs 1Q and 2Q on the fluorescence of Acridine Orange (AO)-BSA complex was determined. The results indicated that these water soluble phthalocyanines (Pcs) can bind to BSA and can be transported in circulatory system. Water soluble nature of both Pcs enhances cellular uptake and these dyes can be used in photodynamic theraphy (PDT).",

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AU - Evren, Didem

AU - Özçeşmeci, Ibrahim

AU - Sesalan, B. Şebnem

AU - Burat, Ayfer Kalkan

PY - 2013

Y1 - 2013

N2 - The interaction between water soluble quinoline substituted phthalocyanines (Pcs) 1Q and 2Q and BSA (bovine serum albumin) was investigated. The binding modes of 1Q and 2Q to BSA was investigated by UV-vis and fluorescence titration experiments. The quenching effect of Pcs 1Q and 2Q on the fluorescence of Acridine Orange (AO)-BSA complex was determined. The results indicated that these water soluble phthalocyanines (Pcs) can bind to BSA and can be transported in circulatory system. Water soluble nature of both Pcs enhances cellular uptake and these dyes can be used in photodynamic theraphy (PDT).

AB - The interaction between water soluble quinoline substituted phthalocyanines (Pcs) 1Q and 2Q and BSA (bovine serum albumin) was investigated. The binding modes of 1Q and 2Q to BSA was investigated by UV-vis and fluorescence titration experiments. The quenching effect of Pcs 1Q and 2Q on the fluorescence of Acridine Orange (AO)-BSA complex was determined. The results indicated that these water soluble phthalocyanines (Pcs) can bind to BSA and can be transported in circulatory system. Water soluble nature of both Pcs enhances cellular uptake and these dyes can be used in photodynamic theraphy (PDT).

KW - Acridineorange

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KW - Fluorescence

KW - Phthalocyanine

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SP - 31

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JF - Synthetic Metals

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Investigation of the biological properties of water soluble quinoline substituted phthalocyanines

Abstract

Keywords

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