Investigation of advanced biological properties of carbon, carbon-boron quantum dots, and copper (II) phthalocyanine nanoconjugates

Mukaddes Özçeşmeci, Selin Gümrükçü, Caner Ünlü, İbrahim Yağız Coşkun, Sadin Özdemir, M. Serkan Yalçın, Gülşah Tollu, İbrahim Özçeşmeci*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Non-peripherally, glycerol terminal groups substituted copper (II) phthalocyanine were non-covalently (electrostatic and/or π–π interaction) attached to carbon (CQD) and carbon-boron quantum dots (CBQD) to form QDs-Pc nanoconjugate systems. Synthesized novel phthalocyanine compounds and QDs-Pc conjugate systems were characterized using different spectroscopic techniques. Various biological assessments were applied to newly synthesized compounds. Conjugates 4 and 5 had a maximal free radical scavenging activity of 71.3% and 68.1% at a 100 mg/L concentration. Compounds exhibited high antidiabetic activities at 200 mg/L. Also, compounds showed significant DNA nuclease activity at all tested concentrations. The most efficient MIC value was obtained as 4 mg/L against Enterococcus hirae and Enterococcus feacalis. This MIC value was further decreased after photodynamic therapy, and it was observed that the antimicrobial effects of the compounds increased. Inhibition of microbial cell viability was obtained as 100% for all compounds. In addition, compounds exerted perfect biofilm inhibitory effects.

Original languageEnglish
Article numbere7423
JournalApplied Organometallic Chemistry
Issue number5
Publication statusPublished - May 2024

Bibliographical note

Publisher Copyright:
© 2024 The Authors. Applied Organometallic Chemistry published by John Wiley & Sons Ltd.


  • DNA cleavage
  • antimicrobial
  • antioxidant
  • biofilm inhibition
  • phthalocyanine
  • quantum dot


Dive into the research topics of 'Investigation of advanced biological properties of carbon, carbon-boron quantum dots, and copper (II) phthalocyanine nanoconjugates'. Together they form a unique fingerprint.

Cite this