TY - GEN
T1 - Investigation into the effects of an individual amino acid on protein function by means of a resonant recognition model
AU - Chrysostomou, Charalambos
AU - Seker, Huseyin
AU - Aydin, Nizamettin
PY - 2011
Y1 - 2011
N2 - Upon identification of a new protein it is important to single out these amino acids responsible for the structural classification of the protein as well as the amino acids contributing to the protein's specific biological characterisation. A novel approach is presented to identify and quantify this cause and effect relationship between amino acid and protein. This exploits the Common Frequency Peak (CFP) that it extracts from the Resonant Recognition Model (RRM). Applicability and robustness of the method are shown on a case study where five different protein families of the influenza A virus Neuraminidase (NA) genes are studied. They include H1N1, H1N2, H2N2, H3N2 and H5N1. The analyses identified five segments, namely three between H1N1 and H5N1 and two between H1N2, H2N2 and H3N2 and suggested that they play a key role in Influenza A NA gene functionality and can potentially be considered as target areas for future antiviral drugs and vaccines such as neuraminidase inhibitors.
AB - Upon identification of a new protein it is important to single out these amino acids responsible for the structural classification of the protein as well as the amino acids contributing to the protein's specific biological characterisation. A novel approach is presented to identify and quantify this cause and effect relationship between amino acid and protein. This exploits the Common Frequency Peak (CFP) that it extracts from the Resonant Recognition Model (RRM). Applicability and robustness of the method are shown on a case study where five different protein families of the influenza A virus Neuraminidase (NA) genes are studied. They include H1N1, H1N2, H2N2, H3N2 and H5N1. The analyses identified five segments, namely three between H1N1 and H5N1 and two between H1N2, H2N2 and H3N2 and suggested that they play a key role in Influenza A NA gene functionality and can potentially be considered as target areas for future antiviral drugs and vaccines such as neuraminidase inhibitors.
KW - Discrete Fourier Transform
KW - Effects of individual amino acids
KW - Influenza A Virus
KW - Neuraminidase
KW - Resonant Recognition Model
UR - http://www.scopus.com/inward/record.url?scp=80054058584&partnerID=8YFLogxK
U2 - 10.1007/978-3-642-24082-9_28
DO - 10.1007/978-3-642-24082-9_28
M3 - Conference contribution
AN - SCOPUS:80054058584
SN - 9783642240812
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 229
EP - 236
BT - Convergence and Hybrid Information Technology - 5th International Conference, ICHIT 2011, Proceedings
T2 - 5th International Conference on Convergence and Hybrid Information Technology, ICHIT 2011
Y2 - 22 September 2011 through 24 September 2011
ER -
