Increased osteoblast adhesion on nanograined hydroxyapatite and tricalcium phosphate calcium titanate composites

Huinan Liu*, Celaletdin Ergun, John W. Halloran, Thomas J. Webster

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Citation (Scopus)


Depending on the coating method utilized and subsequent heat treatments (such as through the use of plasma-spray deposition), inter-diffusion of atomic species across titanium (Ti) and hydroxyapatite (HA) coatings may result. These events may lead to structural and compositional changes that consequently cause unexpected HA phase transformations which may clearly influence the performance of an orthopedic implant. Thus, the objective of the present in vitro study was to compare the cytocompatibility properties of chemistries that may form at the Ti-HA interface, specifically HA, tricalcium phosphate (TCP), Ti doped HA, and those containing calcium titanate (CaTiO3). In doing so, results of this in vitro study showed that osteoblast adhesion increased with greater CaTiO3 substitutions in either HA or TCP Specifically osteoblast adhesion on HA and TCP composites with CaTiO3 was almost 4.5 times higher than over pure HA. Material characterization studies revealed that enhanced osteoblast adhesion on these compacts may be due to increasing shrinkage in the unit lattice parameters and consequent decrease in grain size Although all CaTiO3 composites exhibited excellent osteoblast adhesion results Ca9HPO4(PO4)OH phase formation into TCP/CaTiO33 increased osteoblast adhesion the most; due to these reasons, these materials should be further studied for orthopedic applications.

Original languageEnglish
Title of host publicationMaterials Research Society Symposium Proceedings
PublisherMaterials Research Society
Number of pages6
ISBN (Print)9781604234060
Publication statusPublished - 26 Apr 2006
Event2006 MRS Fall Meeting - Boston, MA, United States
Duration: 27 Nov 20061 Dec 2006

Publication series

NameMaterials Research Society Symposium Proceedings
ISSN (Print)0272-9172


Conference2006 MRS Fall Meeting
Country/TerritoryUnited States
CityBoston, MA


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