In vivo dielectric properties of healthy and benign rat mammary tissues from 500 mhz to 18 ghz

Tuba Yilmaz; Fatma Ates Alkan

doi:10.3390/s20082214

In vivo dielectric properties of healthy and benign rat mammary tissues from 500 mhz to 18 ghz

Tuba Yilmaz^*, Fatma Ates Alkan

^*Corresponding author for this work

Department of Electronics and Communication Engineering

Beykent University

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

This work investigates the in vivo dielectric properties of healthy and benign rat mammary tissues in an attempt to expand the dielectric property knowledge of animal models. The outcomes of this study can enable testing of microwave medical technologies on animal models and interpretation of tissue alteration-dependent in vivo dielectric properties of mammary tissues. Towards this end, in vivo dielectric properties of healthy rat mammary tissues and chemically induced benign rat mammary tumors including low-grade adenosis, sclerosing adenosis, and adenosis were collected with open-ended coaxial probes from 500 MHz to 18 GHz. The in vivo measurements revealed that the dielectric properties of benign rat mammary tumors are higher than the healthy rat mammary tissues by 9.3% to 35.5% and 19.6% to 48.7% for relative permittivity and conductivity, respectively. Furthermore, to our surprise, we found that the grade of the benign tissue affects the dielectric properties for this study. Finally, a comparison with ex vivo healthy human mammary tissue dielectric properties revealed that the healthy rat mammary tissues best replicate the dielectric properties of healthy medium density human samples.

Original language	English
Article number	2214
Journal	Sensors
Volume	20
Issue number	8
DOIs	https://doi.org/10.3390/s20082214
Publication status	Published - 2 Apr 2020

Bibliographical note

Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.

Funding

Funding: This project has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No 750346 and the Istanbul Technical University under grant agreement 41554. This project has received funding from the European Union?s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No 750346 and the Istanbul Technical University under grant agreement 41554. The authors would like to thank the VIVARIUM team for their input to the experimental procedure through fruitful discussions and their help on handling of the animals. The authors would also like to thank the MIDxPRO team for their assistance during the experiments.

Funders	Funder number
VIVARIUM
Horizon 2020 Framework Programme
H2020 Marie Skłodowska-Curie Actions	750346
Istanbul Teknik Üniversitesi	41554

Keywords

DMBA-induced benign tumors
In vivo dielectric properties
Rat mammary tissues

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/s20082214

Cite this

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title = "In vivo dielectric properties of healthy and benign rat mammary tissues from 500 mhz to 18 ghz",

abstract = "This work investigates the in vivo dielectric properties of healthy and benign rat mammary tissues in an attempt to expand the dielectric property knowledge of animal models. The outcomes of this study can enable testing of microwave medical technologies on animal models and interpretation of tissue alteration-dependent in vivo dielectric properties of mammary tissues. Towards this end, in vivo dielectric properties of healthy rat mammary tissues and chemically induced benign rat mammary tumors including low-grade adenosis, sclerosing adenosis, and adenosis were collected with open-ended coaxial probes from 500 MHz to 18 GHz. The in vivo measurements revealed that the dielectric properties of benign rat mammary tumors are higher than the healthy rat mammary tissues by 9.3% to 35.5% and 19.6% to 48.7% for relative permittivity and conductivity, respectively. Furthermore, to our surprise, we found that the grade of the benign tissue affects the dielectric properties for this study. Finally, a comparison with ex vivo healthy human mammary tissue dielectric properties revealed that the healthy rat mammary tissues best replicate the dielectric properties of healthy medium density human samples.",

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AU - Alkan, Fatma Ates

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N2 - This work investigates the in vivo dielectric properties of healthy and benign rat mammary tissues in an attempt to expand the dielectric property knowledge of animal models. The outcomes of this study can enable testing of microwave medical technologies on animal models and interpretation of tissue alteration-dependent in vivo dielectric properties of mammary tissues. Towards this end, in vivo dielectric properties of healthy rat mammary tissues and chemically induced benign rat mammary tumors including low-grade adenosis, sclerosing adenosis, and adenosis were collected with open-ended coaxial probes from 500 MHz to 18 GHz. The in vivo measurements revealed that the dielectric properties of benign rat mammary tumors are higher than the healthy rat mammary tissues by 9.3% to 35.5% and 19.6% to 48.7% for relative permittivity and conductivity, respectively. Furthermore, to our surprise, we found that the grade of the benign tissue affects the dielectric properties for this study. Finally, a comparison with ex vivo healthy human mammary tissue dielectric properties revealed that the healthy rat mammary tissues best replicate the dielectric properties of healthy medium density human samples.

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In vivo dielectric properties of healthy and benign rat mammary tissues from 500 mhz to 18 ghz

Abstract

Bibliographical note

Funding

Keywords

UN SDGs

Access to Document

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