In vitro bioactivity and crystallization behavior of bioactive glass in the system SiO2-CaO-Al2O3-P2O5-Na2O-MgO-CaF2

Melek Erol*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


In this study, bioactivity of glass in the system SiO2-CaO-Al2O3-P2O5-Na2O-MgO-CaF2 was investigated. For this purpose, a glass sample was prepared by the traditional melting method. Crystallization behavior of bioactive glass was also investigated using differential thermal analyses. The Avrami constant of bioactive glass sample calculated according to the Ozawa equation was 3.72 ± 0.4, which indicates bulk crystallization. Using the Matusita-Sakka and the Kissinger equations, activation energy of crystal growth was determined as (394 ± 17) kJ mol-1 and (373 ± 12) kJ mol-1, respectively. These results indicate that the crystallization activation energy data of bioactive glass obtained in this study are accurate and reliable. Bioactivity of the resultant glass sample was analyzed by immersion in simulated body fluid. Scanning electron microscopy, thin film X-ray diffraction, ultraviolet spectroscopy and inductively coupled plasma techniques were used to monitor changes in the glass surface and the simulated body fluid composition. The results revealed that a hydroxyapatite layer was formed on the glass surface after 21 days of immersion in SBF. Formation of the hydroxyapatite layer confirmed the bioactivity of the glass in the system SiO2-CaO-Al2O3-P2O5-Na2O-MgO-CaF2. In addition, physical and mechanical properties of the sample were measured to determine changes in the properties with the immersion time. The results show that bioactive glass maintained its strength during the immersion in a simulated body fluid solution.

Original languageEnglish
Pages (from-to)482-490
Number of pages9
JournalChemical Papers
Issue number4
Publication statusPublished - 2010


  • Bioactive glass
  • Bioactivity
  • Crystallization kinetics
  • Hardness
  • Porosity


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