Hydrophilic Cross-Linked Polymeric Nanofibers Using Electrospinning: Imparting Aqueous Stability to Enable Biomedical Applications

Bianka Golba, Ozlem Ipek Kalaoglu-Altan, Rana Sanyal, Amitav Sanyal*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

13 Citations (Scopus)

Abstract

Polymeric nanofibers are finding a growing number of applications in various areas of biomedical sciences such as diagnostics, therapeutic delivery, and tissue engineering. Since such applications entail interfacing these materials with the biological milieu, it is often necessary that these nanofibers are hydrophilic in nature, yet stable in an aqueous environment. To date, several approaches to impart stabilization to polymeric nanofibers obtained using electrospinning have been developed. Various strategies utilizing chemical cross-linking of polymers have been exploited to impart stabilization of functional nanofibers fabricated using polymers that are soluble in the aqueous environment. This review highlights the various approaches developed to date for providing stabilization to hydrophilic polymeric nanofibers, along with showcasing the utilization of hydrophilic polymeric nanofibers in several biomedical applications.

Original languageEnglish
Pages (from-to)1-17
Number of pages17
JournalACS Applied Polymer Materials
Volume4
Issue number1
DOIs
Publication statusPublished - 14 Jan 2022
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2021 American Chemical Society

Keywords

  • biomedical applictions
  • cross-linking
  • electrospinning
  • hydrophilic surfaces
  • polymeric nanofibers

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