Hybrid modeling of alpha rhythm and the amplitude of low-frequency fluctuations abnormalities in the thalamocortical region and basal ganglia in Alzheimer's disease

Yuksel Cakir*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

A hybrid computational model of thalamocortical circuitry and basal ganglia is proposed to investigate the relation between the fractional amplitude of low-frequency fluctuations (fALFF) in the resting-state functional magnetic resonance imaging (rs-fMRI) in the striatum and electroencephalogram (EEG) changes within the alpha frequency bands in thalamic region in the case of Alzheimer's disease (AD). For that purpose, an Izikhevich neuron model-based network of the basal ganglia region is constructed and connected with the thalamic region which is modeled as neural mass. By considering the neurodegenerative changes in AD, the network dynamics are analyzed. The relation between the neural activity of basal ganglia and AD is investigated by modeling the blood oxygenation level-dependent (BOLD) signal. Decrease in fALFF of slow-4 band in the simulated BOLD signal of the striatum is observed. As the thalamic region receives inhibitory connections from basal ganglia over globus pallidus internal segment (GPi), the parameter changes emulating AD degenerations in the striatum increased the inhibitory effect on the thalamic network, and as a result, slowing in alpha rhythms is observed. It is observed that the decrease in the synaptic strength between the neurons in the striatum has a dominant effect on the slowing in alpha rhythm and also causes a decrease in fALFF of slow-4 band in striatum. This demonstrates a close and causal relation between the decrease in fALFF in the striatum and the slowing in alpha rhythms in the thalamic region in AD.

Original languageEnglish
Pages (from-to)2944-2961
Number of pages18
JournalEuropean Journal of Neuroscience
Volume52
Issue number2
DOIs
Publication statusPublished - 1 Jul 2020

Bibliographical note

Publisher Copyright:
© 2019 Federation of European Neuroscience Societies and John Wiley & Sons Ltd

Funding

This work has been supported by TUBITAK BIDEB (2219).

FundersFunder number
TUBITAK BIDEB2219

    Keywords

    • BOLD signal
    • computational modeling
    • Izikhevich neuron model
    • mass model

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