Hidrofobik i̇laç taşiyicisi olarak akrilik yildiz blok kopolimerler

Translated title of the contribution: Acrylic star block copolymers as hydrophobic drug carriers

Gözde Genç*, Ayşegül Batigün, Oǧuz Bayraktar, Özcan Altintaş, Ümit Tunca, Gürkan Hizal

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Amphiphilic poly(methyl methacrylate)-b-poly(acrylic acid) (PMMA-b-PAA) copolymers with 4 and 6 arms were synthesized by Atomic Transfer Radical Polymerization (ATRP). The polymers were characterized by GPC, H-NMR and FTIR analysis. Polymer samples synthesized at various molecular weights between 18-80 kDa were investigated in terms of maximum loading capacity and critical micelle concentration by fluorescence spectroscopy. 4 arm PMMA-b-PAA (MW 30 kDa) was loaded with hydrophobic model drug indomethacin with an extremely high drug loading efficiency (22.5% drug content). Drug loaded polymer formed a stable and biodegradable complex in aqueous medium.

Translated title of the contributionAcrylic star block copolymers as hydrophobic drug carriers
Original languageTurkish
Title of host publicationProceedings of 2009 14th National Biomedical Engineering Meeting, BIYOMUT 2009
DOIs
Publication statusPublished - 2009
Event2009 14th National Biomedical Engineering Meeting, BIYOMUT 2009 - Balcova, Izmir, Turkey
Duration: 20 May 200922 May 2009

Publication series

NameProceedings of 2009 14th National Biomedical Engineering Meeting, BIYOMUT 2009

Conference

Conference2009 14th National Biomedical Engineering Meeting, BIYOMUT 2009
Country/TerritoryTurkey
CityBalcova, Izmir
Period20/05/0922/05/09

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