TY - JOUR
T1 - G-cimp status prediction of glioblastoma samples using mRNA expression data.
AU - Baysan, Mehmet
AU - Bozdag, Serdar
AU - Cam, Margaret C.
AU - Kotliarova, Svetlana
AU - Ahn, Susie
AU - Walling, Jennifer
AU - Killian, Jonathan K.
AU - Stevenson, Holly
AU - Meltzer, Paul
AU - Fine, Howard A.
PY - 2012
Y1 - 2012
N2 - Glioblastoma Multiforme (GBM) is a tumor with high mortality and no known cure. The dramatic molecular and clinical heterogeneity seen in this tumor has led to attempts to define genetically similar subgroups of GBM with the hope of developing tumor specific therapies targeted to the unique biology within each of these subgroups. Recently, a subset of relatively favorable prognosis GBMs has been identified. These glioma CpG island methylator phenotype, or G-CIMP tumors, have distinct genomic copy number aberrations, DNA methylation patterns, and (mRNA) expression profiles compared to other GBMs. While the standard method for identifying G-CIMP tumors is based on genome-wide DNA methylation data, such data is often not available compared to the more widely available gene expression data. In this study, we have developed and evaluated a method to predict the G-CIMP status of GBM samples based solely on gene expression data.
AB - Glioblastoma Multiforme (GBM) is a tumor with high mortality and no known cure. The dramatic molecular and clinical heterogeneity seen in this tumor has led to attempts to define genetically similar subgroups of GBM with the hope of developing tumor specific therapies targeted to the unique biology within each of these subgroups. Recently, a subset of relatively favorable prognosis GBMs has been identified. These glioma CpG island methylator phenotype, or G-CIMP tumors, have distinct genomic copy number aberrations, DNA methylation patterns, and (mRNA) expression profiles compared to other GBMs. While the standard method for identifying G-CIMP tumors is based on genome-wide DNA methylation data, such data is often not available compared to the more widely available gene expression data. In this study, we have developed and evaluated a method to predict the G-CIMP status of GBM samples based solely on gene expression data.
UR - http://www.scopus.com/inward/record.url?scp=84876435048&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0047839
DO - 10.1371/journal.pone.0047839
M3 - Article
C2 - 23139755
AN - SCOPUS:84876435048
SN - 1932-6203
VL - 7
JO - PLoS ONE
JF - PLoS ONE
IS - 11
ER -
