Abstract
This paper outlines the design of a fractional-order proportional-integral-derivative controller for regulating the induction phase of Propofol infusion in lean and obese patients. The obtained controller is implemented within the pharmacokinetic-pharmacodynamic model and the nonlinear Hill function to conduct closed-loop simulations. The latter are employed using a dataset comprising 24 patients to obtain clinical evaluation results. The design of the controller relies on a generic second-order plus dead time approximation model, which characterizes interpatient variability in response to Propofol infusion within the studied population. The fractional-order proportional-integral-derivative is tuned to achieve sufficient robustness margins ie phase margin, cutoff frequency, and the consideration of the iso-damping properties. The results show no undershoot and a smooth convergence to the desired value of the bispectral index, which indicates the depth of hypnosis.
Original language | English |
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Pages (from-to) | 228-233 |
Number of pages | 6 |
Journal | IFAC-PapersOnLine |
Volume | 58 |
Issue number | 7 |
DOIs | |
Publication status | Published - 1 Jun 2024 |
Event | 4th IFAC Conference on Advances in Proportional-Integral-Derivate Control, PID 2024 - Almeria, Spain Duration: 12 Jun 2024 → 14 Jun 2024 |
Bibliographical note
Publisher Copyright:Copyright © 2024 The Authors.
Keywords
- Closed-Loop Control of Anesthesia
- Fractional-Order PID control
- Obese Patients