Fractional Order PID Control of Propofol Dosage and Optimization in Lean and Obese Patients

Amani R. Ynineb*, Marcian David Mihai, Erhan Yumuk*, Hamed Farbakhsh*, Ghada Ben Othman*, Robin De Keyser*, Cristina Muresan, Isabela Birs*, Dana Copot*, Clara M. Ionescu*

*Corresponding author for this work

Research output: Contribution to journalConference articlepeer-review

Abstract

This paper outlines the design of a fractional-order proportional-integral-derivative controller for regulating the induction phase of Propofol infusion in lean and obese patients. The obtained controller is implemented within the pharmacokinetic-pharmacodynamic model and the nonlinear Hill function to conduct closed-loop simulations. The latter are employed using a dataset comprising 24 patients to obtain clinical evaluation results. The design of the controller relies on a generic second-order plus dead time approximation model, which characterizes interpatient variability in response to Propofol infusion within the studied population. The fractional-order proportional-integral-derivative is tuned to achieve sufficient robustness margins ie phase margin, cutoff frequency, and the consideration of the iso-damping properties. The results show no undershoot and a smooth convergence to the desired value of the bispectral index, which indicates the depth of hypnosis.

Original languageEnglish
Pages (from-to)228-233
Number of pages6
JournalIFAC-PapersOnLine
Volume58
Issue number7
DOIs
Publication statusPublished - 1 Jun 2024
Event4th IFAC Conference on Advances in Proportional-Integral-Derivate Control, PID 2024 - Almeria, Spain
Duration: 12 Jun 202414 Jun 2024

Bibliographical note

Publisher Copyright:
Copyright © 2024 The Authors.

Keywords

  • Closed-Loop Control of Anesthesia
  • Fractional-Order PID control
  • Obese Patients

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