Fe2B magnetic nanoparticles: Synthesis, optimization and cytotoxicity for potential biomedical applications

Sıddıka Mertdinç-Ülküseven*, Farnoud Khakzad, Caner Aslan, Kubra Onbasli, Çağdaş Çevik, Sevim İşçi, Özge Balcı-Çağıran, Havva Yagci Acar, M. Lütfi Öveçoğlu, Duygu Ağaoğulları*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Crystalline iron boride (Fe2B) nanoparticles were successfully synthesized with magnesiothermic reduction reactions triggered by mechanochemical synthesis (MCS) and purified using selective hydrochloric (HCl) acid leaching. Various parameters of MCS were investigated in detail to optimize the synthesis conditions. First, Fe2O3/B/Mg powder mixtures were blended and milled for various durations (up to 8 h) using a high-energy ball mill until Fe2B formation was complete. For the milling optimization, two different ball-to-powder weight ratios (BPRs) were employed: 10/1 and 15/1. Different sizes of milling balls as MCS media were used to investigate their effects on the Fe2B formation. After the MCS experiments, powders were purified with a 4 M hydrochloric acid (HCl) solution to leach out the MgO by-product phase and to obtain pure Fe2B particles. Based on all the optimization studies, Fe2O3/B/Mg powders milled for 6 h using one φ 14.3 mm ball and five φ 12.4 mm balls with a 10/1 BPR and purified were selected as ideal products. Microstructural, thermal, rheological and magnetic properties were determined for the optimum Fe2B nanoparticles. This optimum batch comprising pure Fe2B nanoparticles (with an average size of 35 nm) was tested for biocompatibility (up to 72 h with 200 μg/mL) and specific absorption rate (SAR up to 55 °C) to evaluate its use in biomedical applications. The dose and time-dependent cytotoxicity of poly (acrylic acid) coated Fe2B nanoparticles (PAA-Fe2B) were investigated with cancerous HeLa, MCF7, A549 and MDA-MB-231 and healthy Vero E6 cells. PAA-Fe2B nanoparticles were found to be cytocompatible with Vero E6 cells, HeLa and MCF7 cancer cells. The SAR value of the Fe2B nanoparticles was determined as 9.15 W/g, so the synthesis mechanism and some properties of Fe2B nanoparticles were successfully proposed for possible biomedical applications.

Original languageEnglish
Article number100602
JournalJournal of Science: Advanced Materials and Devices
Volume8
Issue number3
DOIs
Publication statusPublished - Sept 2023

Bibliographical note

Publisher Copyright:
© 2023 Vietnam National University, Hanoi

Funding

This study was financially supported by “The Scientific and Technological Research Council of Türkiye (TUBITAK)” with project number of 118F430. The authors thank to Selçuk University Advanced Technology Research & Application Center for TEM investigations and Kastamonu University Central Research Laboratories for magnetic measurements. The authors thank M. Sc. Faruk Kaya and Prof. Dr. C. Bora Derin for thermochemical calculations. This study was financially supported by “ The Scientific and Technological Research Council of Türkiye (TUBITAK) ” with project number of 118F430 . The authors thank to Selçuk University Advanced Technology Research & Application Center for TEM investigations and Kastamonu University Central Research Laboratories for magnetic measurements. The authors thank M. Sc. Faruk Kaya and Prof. Dr. C. Bora Derin for thermochemical calculations.

FundersFunder number
Kastamonu University Central Research Laboratories
Türkiye Bilimsel ve Teknolojik Araştırma Kurumu118F430

    Keywords

    • Cytotoxicity
    • Iron boride
    • Magnetic property
    • Mechanochemical synthesis
    • Microstructure
    • Specific absorption rate

    Fingerprint

    Dive into the research topics of 'Fe2B magnetic nanoparticles: Synthesis, optimization and cytotoxicity for potential biomedical applications'. Together they form a unique fingerprint.

    Cite this