Fatty acid-based polyurethane films for wound dressing applications

Guncem Gultekin, Cigdem Atalay-Oral, Sibel Erkal, Fikret Sahin, Djursun Karastova, S. Birgul Tantekin-Ersolmaz, F. Seniha Guner

Research output: Contribution to journalArticlepeer-review

62 Citations (Scopus)

Abstract

Fatty acid-based polyurethane films were prepared for use as potential wound dressing material. The polymerization reaction was carried out with or without catalyst. Polymer films were prepared by casting-evaporation technique with or without crosslink-catalyst. The film prepared from uncatalyzed reaction product with crosslink-catalyst gave slightly higher crosslink density. The mechanical tests showed that, the increase in the tensile strength and decrease in the elongation at break is due to the increase in the degree of crosslinking. All films were flexible, and resisted to acid solution. The films prepared without crosslink-catalyst were more hydrophilic, absorbed more water. The highest permeability values were generally obtained for the films prepared without crosslink catalyst. Both the direct contact method and the MMT test were applied for determination of cytotoxicity of polymer films and the polyurethane film prepared from uncatalyzed reaction product without crosslink-catalyst showed better biocompatibility property, closest to the commercial product, Opsite®.

Original languageEnglish
Pages (from-to)421-431
Number of pages11
JournalJournal of Materials Science: Materials in Medicine
Volume20
Issue number1
DOIs
Publication statusPublished - Jan 2009

Funding

Acknowledgments This research is partially funded by the State Planning Organization (DPT) of Turkey. We are grateful to Prof. Dr. Naciye Talinli for discussion of NMR and FTIR results.

FundersFunder number
DPT
Devlet Planlama Örgütü

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