Fabrication of electrospun scaffolds with copper and zinc doped 58S bioactive glasses for bone tissue engineering applications

Zeynep Atasayar; Aysen Akturk; Dilara Nur Dikmetas; Funda Karbancioglu-Guler; Melek Erol-Taygun; Sadriye Küçükbayrak

doi:10.1557/s43580-024-01055-0

Fabrication of electrospun scaffolds with copper and zinc doped 58S bioactive glasses for bone tissue engineering applications

Zeynep Atasayar, Aysen Akturk^*, Dilara Nur Dikmetas, Funda Karbancioglu-Guler, Melek Erol-Taygun, Sadriye Küçükbayrak

^*Corresponding author for this work

Department of Food Engineering

Istanbul Technical University

Research output: Contribution to journal › Article › peer-review

Abstract

In this study, nanocomposite scaffolds were obtained by incorporating 58S bioactive glass (58S) and 58S bioactive glass particles, which contain copper and zinc (CuZn 58S) into the gelatin-chitosan electrospun nanofibers for bone tissue engineering applications. Bioactive glasses were obtained by using the sol–gel process. The obtained nanocomposite scaffolds were characterized by scanning electron microscopy, X-ray diffraction, inductively coupled plasma-optical emission spectroscopy, and antibacterial tests against Escherichia coli (ATCC 25922). The bioactivity of the samples was tested in simulated body fluid. According to the results, CuZn 58S containing nanocomposite scaffolds could be a potential material for bone tissue engineering applications with further modifications of copper content of CuZn 58S.

Original language	English
Journal	MRS Advances
DOIs	https://doi.org/10.1557/s43580-024-01055-0
Publication status	Accepted/In press - 2024

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Publisher Copyright:
© The Author(s), under exclusive licence to The Materials Research Society 2024.

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10.1557/s43580-024-01055-0

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title = "Fabrication of electrospun scaffolds with copper and zinc doped 58S bioactive glasses for bone tissue engineering applications",

abstract = "In this study, nanocomposite scaffolds were obtained by incorporating 58S bioactive glass (58S) and 58S bioactive glass particles, which contain copper and zinc (CuZn 58S) into the gelatin-chitosan electrospun nanofibers for bone tissue engineering applications. Bioactive glasses were obtained by using the sol–gel process. The obtained nanocomposite scaffolds were characterized by scanning electron microscopy, X-ray diffraction, inductively coupled plasma-optical emission spectroscopy, and antibacterial tests against Escherichia coli (ATCC 25922). The bioactivity of the samples was tested in simulated body fluid. According to the results, CuZn 58S containing nanocomposite scaffolds could be a potential material for bone tissue engineering applications with further modifications of copper content of CuZn 58S.",

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doi = "10.1557/s43580-024-01055-0",

language = "English",

journal = "MRS Advances",

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T1 - Fabrication of electrospun scaffolds with copper and zinc doped 58S bioactive glasses for bone tissue engineering applications

AU - Atasayar, Zeynep

AU - Akturk, Aysen

AU - Dikmetas, Dilara Nur

AU - Karbancioglu-Guler, Funda

AU - Erol-Taygun, Melek

AU - Küçükbayrak, Sadriye

PY - 2024

Y1 - 2024

N2 - In this study, nanocomposite scaffolds were obtained by incorporating 58S bioactive glass (58S) and 58S bioactive glass particles, which contain copper and zinc (CuZn 58S) into the gelatin-chitosan electrospun nanofibers for bone tissue engineering applications. Bioactive glasses were obtained by using the sol–gel process. The obtained nanocomposite scaffolds were characterized by scanning electron microscopy, X-ray diffraction, inductively coupled plasma-optical emission spectroscopy, and antibacterial tests against Escherichia coli (ATCC 25922). The bioactivity of the samples was tested in simulated body fluid. According to the results, CuZn 58S containing nanocomposite scaffolds could be a potential material for bone tissue engineering applications with further modifications of copper content of CuZn 58S.

AB - In this study, nanocomposite scaffolds were obtained by incorporating 58S bioactive glass (58S) and 58S bioactive glass particles, which contain copper and zinc (CuZn 58S) into the gelatin-chitosan electrospun nanofibers for bone tissue engineering applications. Bioactive glasses were obtained by using the sol–gel process. The obtained nanocomposite scaffolds were characterized by scanning electron microscopy, X-ray diffraction, inductively coupled plasma-optical emission spectroscopy, and antibacterial tests against Escherichia coli (ATCC 25922). The bioactivity of the samples was tested in simulated body fluid. According to the results, CuZn 58S containing nanocomposite scaffolds could be a potential material for bone tissue engineering applications with further modifications of copper content of CuZn 58S.

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U2 - 10.1557/s43580-024-01055-0

DO - 10.1557/s43580-024-01055-0

M3 - Article

AN - SCOPUS:85212523133

SN - 2059-8521

JO - MRS Advances

JF - MRS Advances

ER -

Fabrication of electrospun scaffolds with copper and zinc doped 58S bioactive glasses for bone tissue engineering applications

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