TY - JOUR
T1 - Fabrication and characterization of bioactive nanoemulsion-based delivery systems
AU - Yilmaz, Azime
AU - Meral, Raciye
AU - Kabli, Mohammad
AU - Ermis, Ertan
AU - Akman, Perihan Kubra
AU - Dertli, Enes
AU - Taylan, Osman
AU - Sagdic, Osman
AU - Yilmaz, Mustafa Tahsin
N1 - Publisher Copyright:
© 2021 ICE Publishing: All rights reserved.
PY - 2021/7/6
Y1 - 2021/7/6
N2 - In this work, a nanoemulsion-based delivery system was developed by encapsulation of different concentrations (0.50%, 0.75% and 1.00% v/v) of oregano essential oil (OEO) within poly(vinyl alcohol). The delivery systems (OEO-loaded nanoemulsion systems (NESs)) were characterized in terms of size distribution, zeta potential and thermal, molecular, microstructural and antifungal properties. The average droplet diameter values were determined to be within the range 70-75 nm, while zeta potential values within the range 3.13-19.90 mV were recorded. An increase in the OEO concentration did not affect the size distribution of nanoemulsions. Change in the concentrations showed no visible differences in Fourier transform infrared spectra. However, for concentrations of 0.50, 0.75 and 1.00%, endothermic peak temperatures were recorded as 94, 105 and 117°C, respectively. The antifungal activity of NESs against the mycelial growth of Aspergillus niger was evaluated, revealing a significant enhancement in the antifungal activity in comparison with that of free OEO. The zone diameter of mycelial growth could be reduced by around 20, 55 and 65% using NESs at levels of 0.50, 0.75 and 1.00% v/v, respectively, over 6 days of incubation. The results of this study revealed the stronger antifungal efficiency of OEO by its encapsulation into NESs as compared with that of free OEO.
AB - In this work, a nanoemulsion-based delivery system was developed by encapsulation of different concentrations (0.50%, 0.75% and 1.00% v/v) of oregano essential oil (OEO) within poly(vinyl alcohol). The delivery systems (OEO-loaded nanoemulsion systems (NESs)) were characterized in terms of size distribution, zeta potential and thermal, molecular, microstructural and antifungal properties. The average droplet diameter values were determined to be within the range 70-75 nm, while zeta potential values within the range 3.13-19.90 mV were recorded. An increase in the OEO concentration did not affect the size distribution of nanoemulsions. Change in the concentrations showed no visible differences in Fourier transform infrared spectra. However, for concentrations of 0.50, 0.75 and 1.00%, endothermic peak temperatures were recorded as 94, 105 and 117°C, respectively. The antifungal activity of NESs against the mycelial growth of Aspergillus niger was evaluated, revealing a significant enhancement in the antifungal activity in comparison with that of free OEO. The zone diameter of mycelial growth could be reduced by around 20, 55 and 65% using NESs at levels of 0.50, 0.75 and 1.00% v/v, respectively, over 6 days of incubation. The results of this study revealed the stronger antifungal efficiency of OEO by its encapsulation into NESs as compared with that of free OEO.
KW - characterisation
KW - molecular properties
KW - nanobiomaterial
UR - http://www.scopus.com/inward/record.url?scp=85116251264&partnerID=8YFLogxK
U2 - 10.1680/jemmr.20.00280
DO - 10.1680/jemmr.20.00280
M3 - Article
AN - SCOPUS:85116251264
SN - 2046-0147
VL - 10
SP - 265
EP - 271
JO - Emerging Materials Research
JF - Emerging Materials Research
IS - 3
ER -