Exploring the Diverse Morphology of Porous Poly(Lactic Acid) Fibers for Developing Long-Term Controlled Antibiotic Delivery Systems

Kwon Ho Seo, Kyung Eun Lee, Meltem Yanilmaz*, Juran Kim*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

In this study, we aimed to explore the morphologies of porous poly(lactic acid) (PLA) fibers through liquid–liquid phase separation, and investigate the relationship among pore formation, physical properties, and antibacterial activities of the fibers for identifying their potential as drug delivery carriers. Antibacterial activities of gentamicin-, kanamycin-, and amikacin-loaded PLA fibers against E. coli and S. epidermidis were evaluated. The antibacterial activity of drugs against E. coli showed the following profile: gentamicin > amikacin > kanamycin; however, S. epidermidis growth was almost completely inhibited immediately after the administration of all three drugs. The efficiency of gentamicin can be attributed to the electrostatic interactions between the positively and negatively charged antibiotic and bacterial cell membrane, respectively. Furthermore, gentamicin-loaded porous PLA fibers were evaluated as drug delivery systems. The cumulative amount of gentamicin in porous PLA nanofibers was considerably higher than that in other PLA fibers for 168 h, followed by 7:3 PLA > 6:4 PLA > 5:5 PLA > non-porous PLA. The 7:3 PLA fibers were projected to be ideal drug carrier candidates for controlled antibiotic release in delivery systems owing to their interconnected internal structure and the largest surface area (55.61 m2 g−1), pore size (42.19 nm), and pore volume (12.78 cm3 g−1).

Original languageEnglish
Article number1272
JournalPharmaceutics
Volume14
Issue number6
DOIs
Publication statusPublished - Jun 2022

Bibliographical note

Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.

Funding

Funding: This research was supported by the Korean Institute of Industrial Technology Convergence (PEH22050) and the National Research Foundation of Korea (NRF-2021R1F1A1061200).

FundersFunder number
Korean Institute of Industrial Technology ConvergencePEH22050
National Research Foundation of KoreaNRF-2021R1F1A1061200

    Keywords

    • aminoglycoside derivatives
    • antibacterial assay
    • controlled drug release
    • drug delivery
    • porous poly(lactic acid) fibers
    • solvent-polymer system

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