Enhancing magnetic resonance imaging tumor detection with fluorescence intensity and lifetime imaging

Ahmet Erten, David Hall, Carl Hoh, Hop S. Tran Cao, Sharmeela Kaushal, Sadik Esener, Robert M. Hoffman, Michael Bouvet, James Chen, Santosh Kesari, Milan Makale*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Early detection is important for many solid cancers but the images provided by ultrasound, magnetic resonance imaging (MRI), and computed tomography applied alone or together, are often not sufficient for decisive early screeningdiagnosis. We demonstrate that MRI augmented with fluorescence intensity (FI) substantially improves detection. Early stage murine pancreatic tumors that could not be identified by blinded, skilled observers using MRI alone, were easily identified with MRI along with FI images acquired with photomultiplier tube detection and offset laser scanning. Moreover, we show that fluorescence lifetime (FLT) imaging enables positive identification of the labeling fluorophore and discriminates it from surrounding tissue autofluorescence. Our data suggest combined-modality imaging with MRI, FI, and FLT can be used to screen and diagnose early tumors.

Original languageEnglish
Article number066012
JournalJournal of Biomedical Optics
Issue number6
Publication statusPublished - Nov 2010
Externally publishedYes


The authors wish to acknowledge the excellent editorial assistance of Ms. Charlene M. Cooper, and the expert imaging assistance provided by Mr. Salman Farshchi-Haydari. This work was in part funded by the National Cancer Institute Grant No. CA109949 and the American Cancer Society Grant No. RSG-05-037-01-CCE (to M.B.), T32 training Grant No. CA121938 (to H.S.T.C.), National Cancer Institute Grant No. CA132971 (to M.B. and AntiCancer Inc.), National Institutes of Health (NIH) Grant No. S10 RR22599-01A1 (to D.J.H) and NIH Grant No. P50 CA128346-01A1.

FundersFunder number
AntiCancer Inc.
National Institutes of HealthS10 RR22599-01A1
American Cancer SocietyCA121938, RSG-05-037-01-CCE
National Cancer InstituteCA109949, R01CA132971


    • cancer detection
    • fluorescence intensity imaging
    • magnetic resonance imaging
    • orthopedic models
    • pancreatic cancer
    • red fluorescent protein


    Dive into the research topics of 'Enhancing magnetic resonance imaging tumor detection with fluorescence intensity and lifetime imaging'. Together they form a unique fingerprint.

    Cite this