Enhanced osteoclast-like cell functions on nanophase ceramics

Thomas J. Webster*, Celaletdin Ergun, Robert H. Doremus, Richard W. Siegel, Rena Bizios

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

443 Citations (Scopus)

Abstract

Synthesis of tartrate-resistant acid phosphatase (TRAP) and formation of resorption pits by osteoclast-like cells, the bone-resorbing cells, on nanophase (that is, material formulations with grain sizes less than 100nm) alumina and hydroxyapatite (HA) were investigated in the present in vitro study. Compared to conventional (that is, grain sizes larger than 100nm) ceramics, synthesis of TRAP was significantly greater in osteoclast-like cells cultured on nanophase alumina and on nanophase HA after 10 and 13 days, respectively. In addition, compared to conventional ceramics, formation of resorption pits was significantly greater by osteoclast-like cells cultured on nanophase alumina and on nanophase HA after 7, 10, and 13 days, respectively. The present study, therefore, demonstrated, for the first time, enhanced osteoclast-like cell function on ceramic surfaces with nanometer-size surface topography.

Original languageEnglish
Pages (from-to)1327-1333
Number of pages7
JournalBiomaterials
Volume22
Issue number11
DOIs
Publication statusPublished - 1 Jun 2001
Externally publishedYes

Keywords

  • Alumina
  • Hydroxyapatite
  • Nanophase
  • Orthopaedic/dental
  • Osteoclasts

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