Encapsulation of L-ascorbic acid via polycaprolactone-polyethylene glycol-casein bioblends

Erhan Ozsagiroglu*, Yuksel Avcibasi Guvenilir

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


The aim of this study was to encapsulate, L-ascorbic acid, in biopolymers in order to obtain (i) enhancing its encapsulation efficiency (ii) increasing drug release ratio using different pH mediums. Microparticles based on polycaprolactone, polyethylene glycol and casein are prepared by spray drying technique. Microparticles are in vitro characterized in terms of yield of production, particle size, morphology, encapsulation efficiency, and drug release. In this manner, the importance of the study is producing of a stable and effective drug encapsulation system by PCL-PEG-CS polymer mixture by spray dryer. We achieved minimum 27.540±0.656 μm particle size with 0.512 m2/g surface area, 84.05% maximum drug loading, and 68.92% drug release ratio at pH 9.6. Release profiles are fitted to previously developed kinetic models to differentiate possible release mechanisms. The Korsmeyer-Peppas model is the best described each release scenario, and the drug release is governed by non-Fickian diffusion at pH 9.6. Our study proposed as an alternative or adjuvants for controlling release of L-ascorbic acid.

Original languageEnglish
Pages (from-to)32-36
Number of pages5
JournalPolish Journal of Chemical Technology
Issue number4
Publication statusPublished - Dec 2015


  • Casein
  • Drug encapsulation
  • L-ascorbic acid
  • Polycaprolactone
  • Polyethylene glycol
  • Spray dryer


Dive into the research topics of 'Encapsulation of L-ascorbic acid via polycaprolactone-polyethylene glycol-casein bioblends'. Together they form a unique fingerprint.

Cite this