Embedding of active proteins and living cells in redox-sensitive hydrogels and nanogels through enzymatic cross-linking

Smriti Singh, Fuat Topuz, Kathrin Hahn, Krystyna Albrecht, Jürgen Groll*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

92 Citations (SciVal)

Abstract

Horseradish peroxidase (HRP) can be used for the enzymatic cross-linking of thiol-functionalized polymers under mild conditions to form hydrogels and nanogels without the need for added H2O2. Cells can be embedded in the hydrogels and proteins can be entrapped and released from the nanogels. These gels are fully degradable under mild and cytocompatible reductive conditions.

Original languageEnglish
Pages (from-to)3000-3003
Number of pages4
JournalAngewandte Chemie - International Edition
Volume52
Issue number10
DOIs
Publication statusPublished - 4 Mar 2013
Externally publishedYes

Funding

FundersFunder number
Seventh Framework Programme215851

    Keywords

    • colloids
    • enzyme catalysis
    • gels
    • horseradish peroxidase (HRP)
    • redox-sensitive materials

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