TY - JOUR
T1 - Electrochemical oxidation mechanism of eugenol on graphene modified carbon paste electrode and its analytical application to pharmaceutical analysis
AU - Yildiz, Gulcemal
AU - Aydogmus, Zeynep
AU - Cinar, M. Emin
AU - Senkal, Filiz
AU - Ozturk, Turan
N1 - Publisher Copyright:
© 2017 Elsevier B.V.
PY - 2017/10/1
Y1 - 2017/10/1
N2 - Electrochemical properties of eugenol were investigated on a graphene modified carbon paste electrode (CPE) by using voltammetric methods, which exhibited a well-defined irreversible peak at about 0.7 V vs Ag/AgCl, NaCl (3 M) in Britton-Robinson buffer at pH 2.0. Mechanism of the electrochemical reaction of eugenol was studied by performing density functional theory (DFT) computations and mass spectroscopic analysis. (CPCM:water)-wB97XD/aug-cc-PVTZ//(CPCM:water)-wB97XD/6-31G(d) level calculations predicted that the formation of product P2, possessing a para-quinoid structure, is preferred rather than the product P1, suggested in the literature, having an ortho-quinoid system. Determination of eugenol in a pharmaceutical sample was realized in the light of the electrochemical findings, and a validated voltammetric method for quantitative analysis of eugenol in a pharmaceutical formulation was proposed. The differential pulse voltammogram (DPV) peak currents were found to be linear in the concentration range of 1.0 × 10−7 to 1.7 × 10−5 M. The limit of detection (LOD) and the limit of quantification (LOQ) were obtained to be 7.0 × 10−9 and 2.3 × 10−8, respectively.
AB - Electrochemical properties of eugenol were investigated on a graphene modified carbon paste electrode (CPE) by using voltammetric methods, which exhibited a well-defined irreversible peak at about 0.7 V vs Ag/AgCl, NaCl (3 M) in Britton-Robinson buffer at pH 2.0. Mechanism of the electrochemical reaction of eugenol was studied by performing density functional theory (DFT) computations and mass spectroscopic analysis. (CPCM:water)-wB97XD/aug-cc-PVTZ//(CPCM:water)-wB97XD/6-31G(d) level calculations predicted that the formation of product P2, possessing a para-quinoid structure, is preferred rather than the product P1, suggested in the literature, having an ortho-quinoid system. Determination of eugenol in a pharmaceutical sample was realized in the light of the electrochemical findings, and a validated voltammetric method for quantitative analysis of eugenol in a pharmaceutical formulation was proposed. The differential pulse voltammogram (DPV) peak currents were found to be linear in the concentration range of 1.0 × 10−7 to 1.7 × 10−5 M. The limit of detection (LOD) and the limit of quantification (LOQ) were obtained to be 7.0 × 10−9 and 2.3 × 10−8, respectively.
KW - DFT
KW - Differential pulse voltammetry (DPV)
KW - Electrochemical properties
KW - Eugenol
KW - Graphene modified carbon paste electrode (CPE)
UR - http://www.scopus.com/inward/record.url?scp=85019882928&partnerID=8YFLogxK
U2 - 10.1016/j.talanta.2017.05.056
DO - 10.1016/j.talanta.2017.05.056
M3 - Article
C2 - 28602182
AN - SCOPUS:85019882928
SN - 0039-9140
VL - 173
SP - 1
EP - 8
JO - Talanta
JF - Talanta
ER -