Electrochemical investigation and DNA-binding studies of valacyclovir-copper(II) complex

Derya Tarinc, Aysegul Golcu*, Mehmet Tumer, Taner Karaoglu, Mehmet Ozsoz

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

The synthesis and the electrochemical characterization of copper(II) complex containing one molecule of antiviral drug, valacyclovir (VAL), is reported. In addition to characterization, the electrochemical properties of the copper(II) complex of VAL ([Cu(VAL)Cl2]) were investigated by cyclic voltammetry (CV) using glassy carbon electrode. The redox properties of the metal complex was reversible and exhibited diffusion controlled process depending on pH. The dependence of intensities of currents and potentials on pH, concentration, scan rate, and nature of the buffer was investigated. The oxidation/reduction mechanism was proposed and discussed. Also, the interaction of copper complex of VAL- with calf thymus double-stranded DNA was studied spectrophotometrically (UV-vis) and electrochemically by using CV at glassy carbon working electrode. Additionally, the cytotoxicity activity of complex has been investigated against the bovine herpes virus type I.

Original languageEnglish
Pages (from-to)140-148
Number of pages9
JournalSynthesis and Reactivity in Inorganic, Metal-Organic and Nano-Metal Chemistry
Volume43
Issue number2
DOIs
Publication statusPublished - 1 Feb 2013
Externally publishedYes

Funding

Received 25 August 2011; accepted 27 December 2011. The authors wish to thank TUBITAK (Project No: 109T020) and KSU (Project No: 2009/3–10) for the financial support. Address correspondence to Aysegul Golcu, Department of Chemistry, Faculty of Science and Letters, University of Kahramanmaras Sutcu Imam, Campuse of Avsar 46100, Kahramanmaras, Turkey. E-mail: [email protected]

FundersFunder number
TUBITAK109T020
Kennesaw State University2009/3–10

    Keywords

    • DNA binding
    • drug-metal complex
    • valacyclovir
    • voltammetry

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