Effects of Cu2+ on stability and composition of water soluble ternary polyacrylic acid-Cu2+-protein complexes against radiation damage

M. I. Mastafaev; A. S. Saraç; A. Y. Erkol; S. Bayülken; B. Dinçer; E. Sezer

doi:10.1007/BF00342455

Effects of Cu²⁺ on stability and composition of water soluble ternary polyacrylic acid-Cu²⁺-protein complexes against radiation damage

M. I. Mastafaev^*, A. S. Saraç, A. Y. Erkol, S. Bayülken, B. Dinçer, E. Sezer

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

The formation of water soluble ternary complexes of polyacrylic acid (PAA) and bovine serum albumin (BSA) in the presence of divalent copper ions was investigated at the neutral pH. Aqueous solutions of PAA, BSA, and their mixture (PAA-BSA, PAA-Cu²⁺-BSA) have been irradiated with ⁶⁰Co γ-rays and the changes occurred have been measured by high performance liquid chromatography (HPLC) and spectrophotometry. Addition of Cu²⁺ ions to PAA-BSA mixture have been shown to protect the PAA and BSA components of ternary PAA-Cu²⁺-BSA complexes against radiation damage. A structural model of ternary polycomplexes was proposed and the mechanism of observed protection effect was discussed.

Original language	English
Pages (from-to)	623-627
Number of pages	5
Journal	Polymer Bulletin
Volume	36
Issue number	5
DOIs	https://doi.org/10.1007/BF00342455
Publication status	Published - 1996

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@article{ec93757959b54d178d2bfa26158b087f,

title = "Effects of Cu2+ on stability and composition of water soluble ternary polyacrylic acid-Cu2+-protein complexes against radiation damage",

abstract = "The formation of water soluble ternary complexes of polyacrylic acid (PAA) and bovine serum albumin (BSA) in the presence of divalent copper ions was investigated at the neutral pH. Aqueous solutions of PAA, BSA, and their mixture (PAA-BSA, PAA-Cu2+-BSA) have been irradiated with 60Co γ-rays and the changes occurred have been measured by high performance liquid chromatography (HPLC) and spectrophotometry. Addition of Cu2+ ions to PAA-BSA mixture have been shown to protect the PAA and BSA components of ternary PAA-Cu2+-BSA complexes against radiation damage. A structural model of ternary polycomplexes was proposed and the mechanism of observed protection effect was discussed.",

author = "Mastafaev, {M. I.} and Sara{\c c}, {A. S.} and Erkol, {A. Y.} and S. Bay{\"u}lken and B. Din{\c c}er and E. Sezer",

year = "1996",

doi = "10.1007/BF00342455",

language = "English",

volume = "36",

pages = "623--627",

journal = "Polymer Bulletin",

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TY - JOUR

T1 - Effects of Cu2+ on stability and composition of water soluble ternary polyacrylic acid-Cu2+-protein complexes against radiation damage

AU - Mastafaev, M. I.

AU - Saraç, A. S.

AU - Erkol, A. Y.

AU - Bayülken, S.

AU - Dinçer, B.

AU - Sezer, E.

PY - 1996

Y1 - 1996

N2 - The formation of water soluble ternary complexes of polyacrylic acid (PAA) and bovine serum albumin (BSA) in the presence of divalent copper ions was investigated at the neutral pH. Aqueous solutions of PAA, BSA, and their mixture (PAA-BSA, PAA-Cu2+-BSA) have been irradiated with 60Co γ-rays and the changes occurred have been measured by high performance liquid chromatography (HPLC) and spectrophotometry. Addition of Cu2+ ions to PAA-BSA mixture have been shown to protect the PAA and BSA components of ternary PAA-Cu2+-BSA complexes against radiation damage. A structural model of ternary polycomplexes was proposed and the mechanism of observed protection effect was discussed.

AB - The formation of water soluble ternary complexes of polyacrylic acid (PAA) and bovine serum albumin (BSA) in the presence of divalent copper ions was investigated at the neutral pH. Aqueous solutions of PAA, BSA, and their mixture (PAA-BSA, PAA-Cu2+-BSA) have been irradiated with 60Co γ-rays and the changes occurred have been measured by high performance liquid chromatography (HPLC) and spectrophotometry. Addition of Cu2+ ions to PAA-BSA mixture have been shown to protect the PAA and BSA components of ternary PAA-Cu2+-BSA complexes against radiation damage. A structural model of ternary polycomplexes was proposed and the mechanism of observed protection effect was discussed.

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U2 - 10.1007/BF00342455

DO - 10.1007/BF00342455

M3 - Article

AN - SCOPUS:0001739863

SN - 0170-0839

VL - 36

SP - 623

EP - 627

JO - Polymer Bulletin

JF - Polymer Bulletin

IS - 5

ER -

Effects of Cu²⁺ on stability and composition of water soluble ternary polyacrylic acid-Cu²⁺-protein complexes against radiation damage

Abstract

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