Effect of Axial Ligand Length on Biological and Anticancer Properties of Axially Disubstituted Silicon Phthalocyanines

H. Yasemin Yenilmez, Nazli Farajzadeh, Nilgün Güler Kuşçulu, Dilek Bahar, Sadin Özdemir, Gülşah Tollu, Mithat Güllü, Zehra Altuntaş Bayır*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

In this study, three new axially disubstituted silicon phthalocyanines (SiPc1–3) and their quaternized phthalocyanine derivatives (QSiPc1–3) were prepared and characterized. The biological properties (antioxidant, antimicrobial, antibiofilm, and microbial cell viability activities) of the water-soluble silicon phthalocyanines were examined, as well. A 1 % DMSO diluted with pure water was used as a solvent in biological activity studies. All the compounds exhibited high antioxidant activity. They displayed efficient antimicrobial and antimicrobial photodynamic therapeutic properties against various microorganisms, especially Gram (+) bacteria. Additionally, they demonstrated high antibiofilm activities against S. aureus and P. aeruginosa. In addition, 100 % bacterial reduction was obtained for all the studied phthalocyanines against E. coli viable cells. Besides, the DNA cleavage and binding features of compounds (QSiPc1–3) were studied using pBR322 DNA and CT-DNA, respectively. Furthermore, the human topoisomerase I enzyme inhibition activities of compounds QSiPc1–3 were studied. Anticancer properties of the water-soluble compounds were investigated using cell proliferation MTT assay. They exhibited anticarcinogenic activity against the human colon cancer cell line (DLD-1). Compounds QSiPc1 and QSiPc3 displayed a high anticarcinogenic effect on the DLD-1 cell line. The obtained results indicated that all the studied compounds may be effective biological agents and anticancer drugs after further investigations.

Original languageEnglish
Article numbere202201167
JournalChemistry and Biodiversity
Volume20
Issue number4
DOIs
Publication statusPublished - Apr 2023

Bibliographical note

Publisher Copyright:
© 2023 Wiley-VHCA AG, Zurich, Switzerland.

Funding

This work was supported financially by the Scientific and Technological Research Council of Türkiye (TÜBİTAK; 220Z023).

FundersFunder number
Türkiye Bilimsel ve Teknolojik Araştırma Kurumu220Z023

    Keywords

    • antibiofilm
    • antioxidant
    • MTT assay
    • silicon phthalocyanine
    • topoisomerase-I enzyme inhibition

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