Dual laser activatable brominated hemicyanine as a highly efficient and photostable multimodal phototherapy agent

Hande Gunduz; Kubra Bilici; Sultan Cetin; Abdullah Muti; Alphan Sennaroglu; Havva Yagci Acar; Safacan Kolemen

doi:10.1016/j.jphotobiol.2021.112171

Dual laser activatable brominated hemicyanine as a highly efficient and photostable multimodal phototherapy agent

Hande Gunduz
, Kubra Bilici
, Sultan Cetin
, Abdullah Muti
, Alphan Sennaroglu^*
, Havva Yagci Acar
, Safacan Kolemen

^*Corresponding author for this work

Koc University

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Dual phototherapy agents have attracted great interest in recent years as they offer enhanced cytotoxicity on cancer cells due to the synergistic effect of photodynamic and photothermal therapies (PDT/PTT). In this study, we demonstrate a brominated hemicyanine (HC-1), which is previously shown as mitochondria targeting PDT agent, can also serve as an effective photosensitizer for PTT for the first time under a single (640 nm or 808 nm) and dual laser (640 nm + 808 nm) irradiation. Generation of reactive oxygen species and photothermal conversion as a function of irradiation wavelength and power were studied. Both single wavelength irradiations caused significant phototoxicity in colon and cervical cancer cells after 5 min of irradiation. However, co-irradiation provided near-complete elimination of cancer cells due to synergistic action. This work introduces an easily accessible small molecule-based synergistic phototherapy agent, which holds a great promise towards the realization of local, rapid and highly efficient treatment modalities against cancer.

Original language	English
Article number	112171
Journal	Journal of Photochemistry and Photobiology B: Biology
Volume	217
DOIs	https://doi.org/10.1016/j.jphotobiol.2021.112171
Publication status	Published - Apr 2021
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2021 Elsevier B.V.

Funding

The authors would like to thank Merve Erkısa, Berkay Civan, and Öznur Baykut for their help on flow cytometry measurements, to Işınsu Baylam for fluorescence quantum yield and 1 O 2 phosphorescence measurements and to Minahil Khan for laser experiments. SK thanks Koç University for financial support. Scheme 1 and TOC were created with BioRender.com .

Funders
Koç Üniversitesi

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cancer
Dual laser irradiation
Hemicyanine
Multimodal phototherapy
Small-molecule photosensitizers

Access to Document

10.1016/j.jphotobiol.2021.112171

Cite this

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title = "Dual laser activatable brominated hemicyanine as a highly efficient and photostable multimodal phototherapy agent",

abstract = "Dual phototherapy agents have attracted great interest in recent years as they offer enhanced cytotoxicity on cancer cells due to the synergistic effect of photodynamic and photothermal therapies (PDT/PTT). In this study, we demonstrate a brominated hemicyanine (HC-1), which is previously shown as mitochondria targeting PDT agent, can also serve as an effective photosensitizer for PTT for the first time under a single (640 nm or 808 nm) and dual laser (640 nm + 808 nm) irradiation. Generation of reactive oxygen species and photothermal conversion as a function of irradiation wavelength and power were studied. Both single wavelength irradiations caused significant phototoxicity in colon and cervical cancer cells after 5 min of irradiation. However, co-irradiation provided near-complete elimination of cancer cells due to synergistic action. This work introduces an easily accessible small molecule-based synergistic phototherapy agent, which holds a great promise towards the realization of local, rapid and highly efficient treatment modalities against cancer.",

keywords = "Cancer, Dual laser irradiation, Hemicyanine, Multimodal phototherapy, Small-molecule photosensitizers",

author = "Hande Gunduz and Kubra Bilici and Sultan Cetin and Abdullah Muti and Alphan Sennaroglu and \{Yagci Acar\}, Havva and Safacan Kolemen",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier B.V.",

year = "2021",

month = apr,

doi = "10.1016/j.jphotobiol.2021.112171",

language = "English",

volume = "217",

journal = "Journal of Photochemistry and Photobiology B: Biology",

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T1 - Dual laser activatable brominated hemicyanine as a highly efficient and photostable multimodal phototherapy agent

AU - Gunduz, Hande

AU - Bilici, Kubra

AU - Cetin, Sultan

AU - Muti, Abdullah

AU - Sennaroglu, Alphan

AU - Yagci Acar, Havva

AU - Kolemen, Safacan

PY - 2021/4

Y1 - 2021/4

N2 - Dual phototherapy agents have attracted great interest in recent years as they offer enhanced cytotoxicity on cancer cells due to the synergistic effect of photodynamic and photothermal therapies (PDT/PTT). In this study, we demonstrate a brominated hemicyanine (HC-1), which is previously shown as mitochondria targeting PDT agent, can also serve as an effective photosensitizer for PTT for the first time under a single (640 nm or 808 nm) and dual laser (640 nm + 808 nm) irradiation. Generation of reactive oxygen species and photothermal conversion as a function of irradiation wavelength and power were studied. Both single wavelength irradiations caused significant phototoxicity in colon and cervical cancer cells after 5 min of irradiation. However, co-irradiation provided near-complete elimination of cancer cells due to synergistic action. This work introduces an easily accessible small molecule-based synergistic phototherapy agent, which holds a great promise towards the realization of local, rapid and highly efficient treatment modalities against cancer.

AB - Dual phototherapy agents have attracted great interest in recent years as they offer enhanced cytotoxicity on cancer cells due to the synergistic effect of photodynamic and photothermal therapies (PDT/PTT). In this study, we demonstrate a brominated hemicyanine (HC-1), which is previously shown as mitochondria targeting PDT agent, can also serve as an effective photosensitizer for PTT for the first time under a single (640 nm or 808 nm) and dual laser (640 nm + 808 nm) irradiation. Generation of reactive oxygen species and photothermal conversion as a function of irradiation wavelength and power were studied. Both single wavelength irradiations caused significant phototoxicity in colon and cervical cancer cells after 5 min of irradiation. However, co-irradiation provided near-complete elimination of cancer cells due to synergistic action. This work introduces an easily accessible small molecule-based synergistic phototherapy agent, which holds a great promise towards the realization of local, rapid and highly efficient treatment modalities against cancer.

KW - Cancer

KW - Dual laser irradiation

KW - Hemicyanine

KW - Multimodal phototherapy

KW - Small-molecule photosensitizers

UR - https://www.scopus.com/pages/publications/85102128562

U2 - 10.1016/j.jphotobiol.2021.112171

DO - 10.1016/j.jphotobiol.2021.112171

M3 - Article

C2 - 33711563

AN - SCOPUS:85102128562

SN - 1011-1344

VL - 217

JO - Journal of Photochemistry and Photobiology B: Biology

JF - Journal of Photochemistry and Photobiology B: Biology

M1 - 112171

ER -

Dual laser activatable brominated hemicyanine as a highly efficient and photostable multimodal phototherapy agent

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

Access to Document

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