Abstract
This study aims to develop procaine-loaded pectin hydrogels for both local anesthetic delivery and wound healing. We investigated the effects of initial drug concentration, pH of initial drug solution, and drying temperature of hydrogel on the drug release behavior of hydrogels. Fourier transform infrared spectroscopy, differential scanning calorimetry, and scanning electron microscopy were used for their characterization. Their swelling percentage, drug loading, and drug release behaviors were determined. Toxic effects of selected hydrogels on the wound healing ability of PCS-201-012 human dermal fibroblast cells and wound dressing properties were also investigated. According to our results, the hydrogels did not affect cell migration. Initial drug concentration, pH of initial drug solution, and drying temperature of hydrogels are crucial on procaine release behavior of pectin-based hydrogels.
| Original language | English |
|---|---|
| Pages (from-to) | 2227-2250 |
| Number of pages | 24 |
| Journal | Polymer Bulletin |
| Volume | 78 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 2021 |
Bibliographical note
Publisher Copyright:© 2020, Springer-Verlag GmbH Germany, part of Springer Nature.
Funding
We sincerely thank Herbstreith & Fox company for providing low-methylated pectin. This work was funded by The Scientific and Technological Research Council of Turkey (TUBITAK) with 115M439 of Project Number.
| Funders | Funder number |
|---|---|
| TUBITAK | 115M439 |
| Türkiye Bilimsel ve Teknolojik Araştirma Kurumu |
Keywords
- Local anesthetic
- Pectin hydrogel
- Procaine
- Wound dressing