Dose evaluation of 142Pr radioisotope by Monte Carlo method in eye brachytherapy

Neslihan Koyuncu; İskender Atilla Reyhancan

doi:10.1016/j.radphyschem.2020.109150

Dose evaluation of 142Pr radioisotope by Monte Carlo method in eye brachytherapy

Neslihan Koyuncu^*, İskender Atilla Reyhancan

^*Corresponding author for this work

Energy Institute

Istanbul Technical University

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Brachytherapy is one of the important methods of cancer treatment. The dosimetry characterization should be performed before any possibility of the new sources is used at a clinical stage. Monte Carlo methods are best to calculate the dosimetry parameters of the radioactive sources. Therefore, dosimetry parameters of beta-emitting ¹⁴²Pr radioactive source were evaluated according to the recommendations of AAPM TG 43 and TG 60 using MCNP5 code. Reference dose rate, geometry function, radial dose function, and anisotropy function were calculated for ¹⁴²Pr brachytherapy seed. Beta particles from ¹⁴²Pr source have short-range and this prevents to damage the healthy tissue. Hence, ¹⁴²Pr is suitable for superficial tumors like eye cancer. As a result, eye geometry was simulated and the dose distribution of ¹⁴²Pr radioactive seed was determined using with MCNP5 code to develop a brachytherapy treatment for eye cancer.

Original language	English
Article number	109150
Journal	Radiation Physics and Chemistry
Volume	177
DOIs	https://doi.org/10.1016/j.radphyschem.2020.109150
Publication status	Published - Dec 2020

Bibliographical note

Publisher Copyright:
© 2020 Elsevier Ltd

Keywords

142Pr
Brachytherapy
Dosimetry
Eye cancer
MCNP5 code
Monte Carlo simulation

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.radphyschem.2020.109150

Cite this

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title = "Dose evaluation of 142Pr radioisotope by Monte Carlo method in eye brachytherapy",

abstract = "Brachytherapy is one of the important methods of cancer treatment. The dosimetry characterization should be performed before any possibility of the new sources is used at a clinical stage. Monte Carlo methods are best to calculate the dosimetry parameters of the radioactive sources. Therefore, dosimetry parameters of beta-emitting 142Pr radioactive source were evaluated according to the recommendations of AAPM TG 43 and TG 60 using MCNP5 code. Reference dose rate, geometry function, radial dose function, and anisotropy function were calculated for 142Pr brachytherapy seed. Beta particles from 142Pr source have short-range and this prevents to damage the healthy tissue. Hence, 142Pr is suitable for superficial tumors like eye cancer. As a result, eye geometry was simulated and the dose distribution of 142Pr radioactive seed was determined using with MCNP5 code to develop a brachytherapy treatment for eye cancer.",

keywords = "142Pr, Brachytherapy, Dosimetry, Eye cancer, MCNP5 code, Monte Carlo simulation",

author = "Neslihan Koyuncu and Reyhancan, {İskender Atilla}",

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year = "2020",

month = dec,

doi = "10.1016/j.radphyschem.2020.109150",

language = "English",

volume = "177",

journal = "Radiation Physics and Chemistry",

issn = "0969-806X",

publisher = "Elsevier Ltd",

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TY - JOUR

T1 - Dose evaluation of 142Pr radioisotope by Monte Carlo method in eye brachytherapy

AU - Koyuncu, Neslihan

AU - Reyhancan, İskender Atilla

PY - 2020/12

Y1 - 2020/12

N2 - Brachytherapy is one of the important methods of cancer treatment. The dosimetry characterization should be performed before any possibility of the new sources is used at a clinical stage. Monte Carlo methods are best to calculate the dosimetry parameters of the radioactive sources. Therefore, dosimetry parameters of beta-emitting 142Pr radioactive source were evaluated according to the recommendations of AAPM TG 43 and TG 60 using MCNP5 code. Reference dose rate, geometry function, radial dose function, and anisotropy function were calculated for 142Pr brachytherapy seed. Beta particles from 142Pr source have short-range and this prevents to damage the healthy tissue. Hence, 142Pr is suitable for superficial tumors like eye cancer. As a result, eye geometry was simulated and the dose distribution of 142Pr radioactive seed was determined using with MCNP5 code to develop a brachytherapy treatment for eye cancer.

AB - Brachytherapy is one of the important methods of cancer treatment. The dosimetry characterization should be performed before any possibility of the new sources is used at a clinical stage. Monte Carlo methods are best to calculate the dosimetry parameters of the radioactive sources. Therefore, dosimetry parameters of beta-emitting 142Pr radioactive source were evaluated according to the recommendations of AAPM TG 43 and TG 60 using MCNP5 code. Reference dose rate, geometry function, radial dose function, and anisotropy function were calculated for 142Pr brachytherapy seed. Beta particles from 142Pr source have short-range and this prevents to damage the healthy tissue. Hence, 142Pr is suitable for superficial tumors like eye cancer. As a result, eye geometry was simulated and the dose distribution of 142Pr radioactive seed was determined using with MCNP5 code to develop a brachytherapy treatment for eye cancer.

KW - 142Pr

KW - Brachytherapy

KW - Dosimetry

KW - Eye cancer

KW - MCNP5 code

KW - Monte Carlo simulation

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Dose evaluation of 142Pr radioisotope by Monte Carlo method in eye brachytherapy

Abstract

Bibliographical note

Keywords

UN SDGs

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