Abstract
Tetrazine mediated inverse Electron Demand Diels–Alder Reaction (IEDDA) is an important modification technique due to its high selectivity and super-fast kinetics. Incorporation of tetrazine moieties on polymer chains requires multistep synthetic pathways and a post-polymerization step leading to functional polymeric materials. Such approaches involve separate syntheses of polymer and the molecule which will be employed in modification. Herein, we introduce a straightforward synthetic approach for direct synthesis of tetrazine groups on polymers as side chains. As model systems, tetrazine functional poly(N-isopropylacrylamide)-and poly(ethylene glycol)-based polymers from corresponding precursor polymers with nitrile moieties as pendant groups are prepared and IEDDA Click Reaction is achieved with trans-cyclooctene derivatives. The click reaction is monitored by both NMR and UV–vis spectroscopies.
Original language | English |
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Pages (from-to) | 673-680 |
Number of pages | 8 |
Journal | Journal of Polymer Science, Part A: Polymer Chemistry |
Volume | 57 |
Issue number | 6 |
DOIs | |
Publication status | Published - 15 Mar 2019 |
Bibliographical note
Publisher Copyright:© 2018 Wiley Periodicals, Inc.
Funding
This work has been financially supported by Türkiye Bilimsel ve Teknolojik Aras¸tirma Kurumu and The Scientific and Technological Research Council of Turkey (TUBITAK, Project # 214M175). This work has been financially supported by T?rkiye Bilimsel ve Teknolojik Ara?tirma Kurumu and The Scientific and Technological Research Council of Turkey (TUBITAK, Project # 214M175).
Funders | Funder number |
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TUBITAK | |
Türkiye Bilimsel ve Teknolojik Araştırma Kurumu | 214M175 |
Keywords
- ATRP
- Diels–Alder click
- functionalization of polymers
- IEDDA
- modification
- post-polymerization
- tetrazine