Differential Pulse Voltammetric Determination of Montelukast in Tablets and Human Plasma by Using Chitosan Modified Carbon Paste Electrode

Gülcemal Yildiz; Zeynep Aydoǧmuş; Jean Michel Kauffmann

doi:10.1002/elan.201300077

Differential Pulse Voltammetric Determination of Montelukast in Tablets and Human Plasma by Using Chitosan Modified Carbon Paste Electrode

Gülcemal Yildiz, Zeynep Aydoǧmuş^*, Jean Michel Kauffmann

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Electrochemical reduction and determination of montelukast (MKS) was studied in methanol - 0.1M HCl solution (1:1, v/v) by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) at chitosan modified carbon paste electrode. The linear range was 1.70×10^-7-1.83×10^-5M for DPV analysis. Limit of detection (LOD) and limit of quantification (LOQ) were 5.32×10^-8M and 1.61×10^-7M, respectively. The developed method was successfully applied to the determination of MKS in tablets and spiked human plasma. The results obtained were in good agreement with those obtained using a reported spectrofluorimetric technique.

Original language	English
Pages (from-to)	1796-1802
Number of pages	7
Journal	Electroanalysis
Volume	25
Issue number	7
DOIs	https://doi.org/10.1002/elan.201300077
Publication status	Published - Jul 2013

Keywords

Chitosan modified carbon paste electrode
Drugs
Montelukast
Plasma
Voltammetry

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10.1002/elan.201300077

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title = "Differential Pulse Voltammetric Determination of Montelukast in Tablets and Human Plasma by Using Chitosan Modified Carbon Paste Electrode",

abstract = "Electrochemical reduction and determination of montelukast (MKS) was studied in methanol - 0.1M HCl solution (1:1, v/v) by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) at chitosan modified carbon paste electrode. The linear range was 1.70×10-7-1.83×10-5M for DPV analysis. Limit of detection (LOD) and limit of quantification (LOQ) were 5.32×10-8M and 1.61×10-7M, respectively. The developed method was successfully applied to the determination of MKS in tablets and spiked human plasma. The results obtained were in good agreement with those obtained using a reported spectrofluorimetric technique.",

keywords = "Chitosan modified carbon paste electrode, Drugs, Montelukast, Plasma, Voltammetry",

author = "G{\"u}lcemal Yildiz and Zeynep Aydoǧmu{\c s} and Kauffmann, {Jean Michel}",

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language = "English",

volume = "25",

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TY - JOUR

T1 - Differential Pulse Voltammetric Determination of Montelukast in Tablets and Human Plasma by Using Chitosan Modified Carbon Paste Electrode

AU - Yildiz, Gülcemal

AU - Aydoǧmuş, Zeynep

AU - Kauffmann, Jean Michel

PY - 2013/7

Y1 - 2013/7

N2 - Electrochemical reduction and determination of montelukast (MKS) was studied in methanol - 0.1M HCl solution (1:1, v/v) by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) at chitosan modified carbon paste electrode. The linear range was 1.70×10-7-1.83×10-5M for DPV analysis. Limit of detection (LOD) and limit of quantification (LOQ) were 5.32×10-8M and 1.61×10-7M, respectively. The developed method was successfully applied to the determination of MKS in tablets and spiked human plasma. The results obtained were in good agreement with those obtained using a reported spectrofluorimetric technique.

AB - Electrochemical reduction and determination of montelukast (MKS) was studied in methanol - 0.1M HCl solution (1:1, v/v) by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) at chitosan modified carbon paste electrode. The linear range was 1.70×10-7-1.83×10-5M for DPV analysis. Limit of detection (LOD) and limit of quantification (LOQ) were 5.32×10-8M and 1.61×10-7M, respectively. The developed method was successfully applied to the determination of MKS in tablets and spiked human plasma. The results obtained were in good agreement with those obtained using a reported spectrofluorimetric technique.

KW - Chitosan modified carbon paste electrode

KW - Drugs

KW - Montelukast

KW - Plasma

KW - Voltammetry

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U2 - 10.1002/elan.201300077

DO - 10.1002/elan.201300077

M3 - Article

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SN - 1040-0397

VL - 25

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JO - Electroanalysis

JF - Electroanalysis

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Differential Pulse Voltammetric Determination of Montelukast in Tablets and Human Plasma by Using Chitosan Modified Carbon Paste Electrode

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