Diet, lifestyle and cardiovascular diseases: Linking pathophysiology to cardioprotective effects of natural bioactive compounds

Javad Sharifi-Rad; Célia F. Rodrigues; Farukh Sharopov; Anca Oana Docea; Asli Can Karaca; Mehdi Sharifi-Rad; Derya Kahveci Karincaoglu; Gözde Gülseren; Ezgi Şenol; Evren Demircan; Yasaman Taheri; Hafiz Ansar Rasul Suleria; Beraat Özçelik; Kadriye Nur Kasapoğlu; Mine Gültekin-Özgüven; Ceren Daşkaya-Dikmen; William C. Cho; Natália Martins; Daniela Calina

doi:10.3390/ijerph17072326

Diet, lifestyle and cardiovascular diseases: Linking pathophysiology to cardioprotective effects of natural bioactive compounds

Javad Sharifi-Rad, Célia F. Rodrigues, Farukh Sharopov, Anca Oana Docea, Asli Can Karaca, Mehdi Sharifi-Rad, Derya Kahveci Karincaoglu, Gözde Gülseren, Ezgi Şenol, Evren Demircan, Yasaman Taheri, Hafiz Ansar Rasul Suleria, Beraat Özçelik, Kadriye Nur Kasapoğlu, Mine Gültekin-Özgüven, Ceren Daşkaya-Dikmen, William C. Cho^*, Natália Martins, Daniela Calina

^*Corresponding author for this work

Department of Food Engineering

Research output: Contribution to journal › Review article › peer-review

168 Citations (Scopus)

Abstract

Heart and blood vessels disorders comprise one of the main causes of death worldwide. Pharmacologically active natural compounds have been used as a complementary therapy in cardiovascular disease around the world in a traditional way. Dietary, natural bioactive compounds, as well as healthy lifestyles, are considered to prevent coronary artery diseases. Pre-clinical and clinical studies reported that consumption of plant-food bioactive derivatives including polyphenolic compounds, peptides, oligosaccharides, vitamins, unsaturated fatty acids possess protective effects on cardiovascular diseases. This review aims to summarize the cardiovascular risk factors, pre-clinical studies and clinical trials related to cardioprotective properties of the plant-food-derived bioactive compounds. Molecular mechanisms by the natural bioactive compounds exert their cardiovascular protective properties have also been highlighted.

Original language	English
Article number	2326
Journal	International Journal of Environmental Research and Public Health
Volume	17
Issue number	7
DOIs	https://doi.org/10.3390/ijerph17072326
Publication status	Published - 1 Apr 2020

Bibliographical note

Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.

Funding

Acknowledgments: N. Martins would like to thank the Portuguese Foundation for Science and Technology (FCT–Portugal) for the Strategic project ref. UID/BIM/04293/2013 and “NORTE2020 - Programa Operacional Regional do Norte” (NORTE-01-0145-FEDER-000012) and C. F. Rodrigues for the UID/EQU/00511/2019 Project—Laboratory of Process Engineering, Environment, Biotechnology, and Energy—LEPABE financed by national funds through FCT/MCTES (PIDDAC). N. Martins would like to thank the Portuguese Foundation for Science and Technology (FCT-Portugal) for the Strategic project ref. UID/BIM/04293/2013 and ?NORTE2020 - Programa Operacional Regional do Norte? (NORTE-01-0145-FEDER-000012) and C. F. Rodrigues for the UID/EQU/00511/2019 Project-Laboratory of Process Engineering, Environment, Biotechnology, and Energy-LEPABE financed by national funds through FCT/MCTES (PIDDAC).

Funders	Funder number
FCT-Portugal
FCT/MCTES
Fundação para a Ciência e a Tecnologia	UID/BIM/04293/2013, UID/EQU/00511/2019, NORTE-01-0145-FEDER-000012
Ministério da Ciência, Tecnologia e Ensino Superior

Keywords

Arterial hypertension
Atherosclerosis
Cardio-protective pharmacotherapy
Classical and emerging risk factors
Coronary artery disease
Diabetes
Diet
Food
Lifestyle
Plant-food bioactive compounds

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/ijerph17072326

Cite this

Sharifi-Rad, J., Rodrigues, C. F., Sharopov, F., Docea, A. O., Karaca, A. C., Sharifi-Rad, M., Karincaoglu, D. K., Gülseren, G., Şenol, E., Demircan, E., Taheri, Y., Suleria, H. A. R., Özçelik, B., Kasapoğlu, K. N., Gültekin-Özgüven, M., Daşkaya-Dikmen, C., Cho, W. C., Martins, N., & Calina, D. (2020). Diet, lifestyle and cardiovascular diseases: Linking pathophysiology to cardioprotective effects of natural bioactive compounds. International Journal of Environmental Research and Public Health, 17(7), Article 2326. https://doi.org/10.3390/ijerph17072326

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title = "Diet, lifestyle and cardiovascular diseases: Linking pathophysiology to cardioprotective effects of natural bioactive compounds",

abstract = "Heart and blood vessels disorders comprise one of the main causes of death worldwide. Pharmacologically active natural compounds have been used as a complementary therapy in cardiovascular disease around the world in a traditional way. Dietary, natural bioactive compounds, as well as healthy lifestyles, are considered to prevent coronary artery diseases. Pre-clinical and clinical studies reported that consumption of plant-food bioactive derivatives including polyphenolic compounds, peptides, oligosaccharides, vitamins, unsaturated fatty acids possess protective effects on cardiovascular diseases. This review aims to summarize the cardiovascular risk factors, pre-clinical studies and clinical trials related to cardioprotective properties of the plant-food-derived bioactive compounds. Molecular mechanisms by the natural bioactive compounds exert their cardiovascular protective properties have also been highlighted.",

keywords = "Arterial hypertension, Atherosclerosis, Cardio-protective pharmacotherapy, Classical and emerging risk factors, Coronary artery disease, Diabetes, Diet, Food, Lifestyle, Plant-food bioactive compounds",

author = "Javad Sharifi-Rad and Rodrigues, {C{\'e}lia F.} and Farukh Sharopov and Docea, {Anca Oana} and Karaca, {Asli Can} and Mehdi Sharifi-Rad and Karincaoglu, {Derya Kahveci} and G{\"o}zde G{\"u}lseren and Ezgi {\c S}enol and Evren Demircan and Yasaman Taheri and Suleria, {Hafiz Ansar Rasul} and Beraat {\"O}z{\c c}elik and Kasapoğlu, {Kadriye Nur} and Mine G{\"u}ltekin-{\"O}zg{\"u}ven and Ceren Da{\c s}kaya-Dikmen and Cho, {William C.} and Nat{\'a}lia Martins and Daniela Calina",

note = "Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2020",

month = apr,

day = "1",

doi = "10.3390/ijerph17072326",

language = "English",

volume = "17",

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Sharifi-Rad, J, Rodrigues, CF, Sharopov, F, Docea, AO, Karaca, AC, Sharifi-Rad, M, Karincaoglu, DK, Gülseren, G, Şenol, E, Demircan, E, Taheri, Y, Suleria, HAR, Özçelik, B , Kasapoğlu, KN, Gültekin-Özgüven, M, Daşkaya-Dikmen, C, Cho, WC, Martins, N & Calina, D 2020, 'Diet, lifestyle and cardiovascular diseases: Linking pathophysiology to cardioprotective effects of natural bioactive compounds', International Journal of Environmental Research and Public Health, vol. 17, no. 7, 2326. https://doi.org/10.3390/ijerph17072326

Diet, lifestyle and cardiovascular diseases: Linking pathophysiology to cardioprotective effects of natural bioactive compounds. / Sharifi-Rad, Javad; Rodrigues, Célia F.; Sharopov, Farukh et al.
In: International Journal of Environmental Research and Public Health, Vol. 17, No. 7, 2326, 01.04.2020.

Research output: Contribution to journal › Review article › peer-review

TY - JOUR

T1 - Diet, lifestyle and cardiovascular diseases

T2 - Linking pathophysiology to cardioprotective effects of natural bioactive compounds

AU - Sharifi-Rad, Javad

AU - Rodrigues, Célia F.

AU - Sharopov, Farukh

AU - Docea, Anca Oana

AU - Karaca, Asli Can

AU - Sharifi-Rad, Mehdi

AU - Karincaoglu, Derya Kahveci

AU - Gülseren, Gözde

AU - Şenol, Ezgi

AU - Demircan, Evren

AU - Taheri, Yasaman

AU - Suleria, Hafiz Ansar Rasul

AU - Özçelik, Beraat

AU - Kasapoğlu, Kadriye Nur

AU - Gültekin-Özgüven, Mine

AU - Daşkaya-Dikmen, Ceren

AU - Cho, William C.

AU - Martins, Natália

AU - Calina, Daniela

PY - 2020/4/1

Y1 - 2020/4/1

N2 - Heart and blood vessels disorders comprise one of the main causes of death worldwide. Pharmacologically active natural compounds have been used as a complementary therapy in cardiovascular disease around the world in a traditional way. Dietary, natural bioactive compounds, as well as healthy lifestyles, are considered to prevent coronary artery diseases. Pre-clinical and clinical studies reported that consumption of plant-food bioactive derivatives including polyphenolic compounds, peptides, oligosaccharides, vitamins, unsaturated fatty acids possess protective effects on cardiovascular diseases. This review aims to summarize the cardiovascular risk factors, pre-clinical studies and clinical trials related to cardioprotective properties of the plant-food-derived bioactive compounds. Molecular mechanisms by the natural bioactive compounds exert their cardiovascular protective properties have also been highlighted.

AB - Heart and blood vessels disorders comprise one of the main causes of death worldwide. Pharmacologically active natural compounds have been used as a complementary therapy in cardiovascular disease around the world in a traditional way. Dietary, natural bioactive compounds, as well as healthy lifestyles, are considered to prevent coronary artery diseases. Pre-clinical and clinical studies reported that consumption of plant-food bioactive derivatives including polyphenolic compounds, peptides, oligosaccharides, vitamins, unsaturated fatty acids possess protective effects on cardiovascular diseases. This review aims to summarize the cardiovascular risk factors, pre-clinical studies and clinical trials related to cardioprotective properties of the plant-food-derived bioactive compounds. Molecular mechanisms by the natural bioactive compounds exert their cardiovascular protective properties have also been highlighted.

KW - Arterial hypertension

KW - Atherosclerosis

KW - Cardio-protective pharmacotherapy

KW - Classical and emerging risk factors

KW - Coronary artery disease

KW - Diabetes

KW - Diet

KW - Food

KW - Lifestyle

KW - Plant-food bioactive compounds

UR - http://www.scopus.com/inward/record.url?scp=85082792264&partnerID=8YFLogxK

U2 - 10.3390/ijerph17072326

DO - 10.3390/ijerph17072326

M3 - Review article

C2 - 32235611

AN - SCOPUS:85082792264

SN - 1661-7827

VL - 17

JO - International Journal of Environmental Research and Public Health

JF - International Journal of Environmental Research and Public Health

IS - 7

M1 - 2326

ER -

Diet, lifestyle and cardiovascular diseases: Linking pathophysiology to cardioprotective effects of natural bioactive compounds

Abstract

Bibliographical note

Funding

Keywords

UN SDGs

Access to Document

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Cite this