Development of a cysteine responsive chlorinated hemicyanine for image-guided dual phototherapy

Samira Savani; Kubra Onbasli; Hande Gunduz; Eda Aydındogan; Merve Erkısa; Abdullah Muti; Minahil Khan; Alphan Sennaroglu; Engin Ulukaya; Havva Yagci Acar; Safacan Kolemen

doi:10.1016/j.bioorg.2022.105725

Development of a cysteine responsive chlorinated hemicyanine for image-guided dual phototherapy

Samira Savani, Kubra Onbasli, Hande Gunduz, Eda Aydındogan, Merve Erkısa, Abdullah Muti, Minahil Khan, Alphan Sennaroglu, Engin Ulukaya, Havva Yagci Acar^*, Safacan Kolemen

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

A cysteine (Cys) activatable chlorinated hemicyanine (Cl-Cys) was introduced as a tumour selective image-guided dual phototherapy agent. Cl-Cys exhibited a significant turn on response in its near-IR emission signal and activated its singlet oxygen generation as well as photothermal conversion potentials upon reacting with Cys. The laser irradiation of Cl-Cys induced significant cell death in cancer cells with high Cys level, while it stayed deactivated and non-emissive in a healthy cell line. A profound synergistic PDT/PTT effect was observed at high doses. Remarkably, Cl-Cys marks the first ever example of Cys-responsive small organic-based therapeutic agent and holds a great promise to develop new activity-based photosensitizers for dual phototherapy action.

Original language	English
Article number	105725
Journal	Bioorganic Chemistry
Volume	122
DOIs	https://doi.org/10.1016/j.bioorg.2022.105725
Publication status	Published - May 2022
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2022 Elsevier Inc.

Funding

SK thanks BAGEP award of Science Academy for the financial support. Authors thank Kübra Nur Özvural Sertçelik for the graphical abstract.

Funders	Funder number
Bilim Akademisi

Keywords

Cancer
Cysteine
Hemicyanine
Photosensitizers
Phototherapy
Theranostics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bioorg.2022.105725

Cite this

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title = "Development of a cysteine responsive chlorinated hemicyanine for image-guided dual phototherapy",

abstract = "A cysteine (Cys) activatable chlorinated hemicyanine (Cl-Cys) was introduced as a tumour selective image-guided dual phototherapy agent. Cl-Cys exhibited a significant turn on response in its near-IR emission signal and activated its singlet oxygen generation as well as photothermal conversion potentials upon reacting with Cys. The laser irradiation of Cl-Cys induced significant cell death in cancer cells with high Cys level, while it stayed deactivated and non-emissive in a healthy cell line. A profound synergistic PDT/PTT effect was observed at high doses. Remarkably, Cl-Cys marks the first ever example of Cys-responsive small organic-based therapeutic agent and holds a great promise to develop new activity-based photosensitizers for dual phototherapy action.",

keywords = "Cancer, Cysteine, Hemicyanine, Photosensitizers, Phototherapy, Theranostics",

author = "Samira Savani and Kubra Onbasli and Hande Gunduz and Eda Aydındogan and Merve Erkısa and Abdullah Muti and Minahil Khan and Alphan Sennaroglu and Engin Ulukaya and {Yagci Acar}, Havva and Safacan Kolemen",

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year = "2022",

month = may,

doi = "10.1016/j.bioorg.2022.105725",

language = "English",

volume = "122",

journal = "Bioorganic Chemistry",

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T1 - Development of a cysteine responsive chlorinated hemicyanine for image-guided dual phototherapy

AU - Savani, Samira

AU - Onbasli, Kubra

AU - Gunduz, Hande

AU - Aydındogan, Eda

AU - Erkısa, Merve

AU - Muti, Abdullah

AU - Khan, Minahil

AU - Sennaroglu, Alphan

AU - Ulukaya, Engin

AU - Yagci Acar, Havva

AU - Kolemen, Safacan

PY - 2022/5

Y1 - 2022/5

N2 - A cysteine (Cys) activatable chlorinated hemicyanine (Cl-Cys) was introduced as a tumour selective image-guided dual phototherapy agent. Cl-Cys exhibited a significant turn on response in its near-IR emission signal and activated its singlet oxygen generation as well as photothermal conversion potentials upon reacting with Cys. The laser irradiation of Cl-Cys induced significant cell death in cancer cells with high Cys level, while it stayed deactivated and non-emissive in a healthy cell line. A profound synergistic PDT/PTT effect was observed at high doses. Remarkably, Cl-Cys marks the first ever example of Cys-responsive small organic-based therapeutic agent and holds a great promise to develop new activity-based photosensitizers for dual phototherapy action.

AB - A cysteine (Cys) activatable chlorinated hemicyanine (Cl-Cys) was introduced as a tumour selective image-guided dual phototherapy agent. Cl-Cys exhibited a significant turn on response in its near-IR emission signal and activated its singlet oxygen generation as well as photothermal conversion potentials upon reacting with Cys. The laser irradiation of Cl-Cys induced significant cell death in cancer cells with high Cys level, while it stayed deactivated and non-emissive in a healthy cell line. A profound synergistic PDT/PTT effect was observed at high doses. Remarkably, Cl-Cys marks the first ever example of Cys-responsive small organic-based therapeutic agent and holds a great promise to develop new activity-based photosensitizers for dual phototherapy action.

KW - Cancer

KW - Cysteine

KW - Hemicyanine

KW - Photosensitizers

KW - Phototherapy

KW - Theranostics

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U2 - 10.1016/j.bioorg.2022.105725

DO - 10.1016/j.bioorg.2022.105725

M3 - Article

C2 - 35316664

AN - SCOPUS:85126525592

SN - 0045-2068

VL - 122

JO - Bioorganic Chemistry

JF - Bioorganic Chemistry

M1 - 105725

ER -

Development of a cysteine responsive chlorinated hemicyanine for image-guided dual phototherapy

Abstract

Bibliographical note

Funding

Keywords

UN SDGs

Access to Document

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