Development and validation of spectrophotometric methods for determination of some cephalosporin group antibiotic drugs

Derya Tarinc; Aysegul Golcu

doi:10.1134/S1061934812020128

Development and validation of spectrophotometric methods for determination of some cephalosporin group antibiotic drugs

Derya Tarinc^*, Aysegul Golcu

^*Corresponding author for this work

Kahramanmaras Sutcu Imam University

Research output: Contribution to journal › Review article › peer-review

7 Citations (Scopus)

Abstract

A simple and direct spectrophotometric method is developed for the determination of some cephalosporin group antibiotic drugs such as Loracarbef (Lora), Ceftazidime (Ceft), and Cefaclor (Cefa) in bulk and pharmaceutical formulations. The optimum conditions for the analysis of aqueous solutions of drugs are studied. Under the optimum conditions, the three drugs could be assayed in the concentration range 2-9 × 10 ^-5, 2-6 × 10 ^-5, and 3-9 × 10 ^-5 M for Lora, Ceft and Cefa, respectively. Detection and quantification limits are calculated. The obtained results showed good recoveries of 100.4, 107.4, and 100.7% for Lora, Ceft, and Cefa, respectively. The results obtained are compared favorably with those given by literature methods.

Original language	English
Pages (from-to)	144-150
Number of pages	7
Journal	Journal of Analytical Chemistry
Volume	67
Issue number	2
DOIs	https://doi.org/10.1134/S1061934812020128
Publication status	Published - Feb 2012
Externally published	Yes

Funding

ACKNOWLEDGMENTS This research was supported by a grant TUBITAK. (Grand no. 105T371) for Assoc. Prof. Dr. Aysegul Golcu.

Funders	Funder number
TUBITAK

Keywords

antibiotic drugs
spectrophotometric determination
validation

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10.1134/S1061934812020128

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abstract = "A simple and direct spectrophotometric method is developed for the determination of some cephalosporin group antibiotic drugs such as Loracarbef (Lora), Ceftazidime (Ceft), and Cefaclor (Cefa) in bulk and pharmaceutical formulations. The optimum conditions for the analysis of aqueous solutions of drugs are studied. Under the optimum conditions, the three drugs could be assayed in the concentration range 2-9 × 10 -5, 2-6 × 10 -5, and 3-9 × 10 -5 M for Lora, Ceft and Cefa, respectively. Detection and quantification limits are calculated. The obtained results showed good recoveries of 100.4, 107.4, and 100.7% for Lora, Ceft, and Cefa, respectively. The results obtained are compared favorably with those given by literature methods.",

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AU - Golcu, Aysegul

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AB - A simple and direct spectrophotometric method is developed for the determination of some cephalosporin group antibiotic drugs such as Loracarbef (Lora), Ceftazidime (Ceft), and Cefaclor (Cefa) in bulk and pharmaceutical formulations. The optimum conditions for the analysis of aqueous solutions of drugs are studied. Under the optimum conditions, the three drugs could be assayed in the concentration range 2-9 × 10 -5, 2-6 × 10 -5, and 3-9 × 10 -5 M for Lora, Ceft and Cefa, respectively. Detection and quantification limits are calculated. The obtained results showed good recoveries of 100.4, 107.4, and 100.7% for Lora, Ceft, and Cefa, respectively. The results obtained are compared favorably with those given by literature methods.

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Development and validation of spectrophotometric methods for determination of some cephalosporin group antibiotic drugs

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