Determination of alginate copolymer in pharmaceutical formulations by micellar electrokinetic chromatography

Nevin Öztekin; Selda Başkan; F. Bedia Erim

doi:10.1016/j.jchromb.2006.12.025

Determination of alginate copolymer in pharmaceutical formulations by micellar electrokinetic chromatography

Nevin Öztekin
, Selda Başkan
, F. Bedia Erim^*

^*Corresponding author for this work

Department of Chemistry

Istanbul Technical University

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

A micellar electrokinetic chromatography method was developed for the determination and quantification of sodium alginate. The alginate peak migrated in the very short time of 1.33 min and calibrated easily though the polydisperse properties of alginates. The minimum detection limit (LOD) of the method was calculated as 0.393 mg/ml. This analysis method was successfully applied to the alginate quantification in an antacid pharmaceutical formulation. Precise and reproducible analysis results were obtained, with liquid formulations injected directly without any pre-separation process.

Original language	English
Pages (from-to)	488-492
Number of pages	5
Journal	Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
Volume	850
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jchromb.2006.12.025
Publication status	Published - 1 May 2007

Keywords

Alginate
Antacid
Capillary electrophoresis
MEKC

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10.1016/j.jchromb.2006.12.025

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title = "Determination of alginate copolymer in pharmaceutical formulations by micellar electrokinetic chromatography",

abstract = "A micellar electrokinetic chromatography method was developed for the determination and quantification of sodium alginate. The alginate peak migrated in the very short time of 1.33 min and calibrated easily though the polydisperse properties of alginates. The minimum detection limit (LOD) of the method was calculated as 0.393 mg/ml. This analysis method was successfully applied to the alginate quantification in an antacid pharmaceutical formulation. Precise and reproducible analysis results were obtained, with liquid formulations injected directly without any pre-separation process.",

keywords = "Alginate, Antacid, Capillary electrophoresis, MEKC",

author = "Nevin {\"O}ztekin and Selda Ba{\c s}kan and Erim, \{F. Bedia\}",

year = "2007",

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doi = "10.1016/j.jchromb.2006.12.025",

language = "English",

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TY - JOUR

T1 - Determination of alginate copolymer in pharmaceutical formulations by micellar electrokinetic chromatography

AU - Öztekin, Nevin

AU - Başkan, Selda

AU - Erim, F. Bedia

PY - 2007/5/1

Y1 - 2007/5/1

N2 - A micellar electrokinetic chromatography method was developed for the determination and quantification of sodium alginate. The alginate peak migrated in the very short time of 1.33 min and calibrated easily though the polydisperse properties of alginates. The minimum detection limit (LOD) of the method was calculated as 0.393 mg/ml. This analysis method was successfully applied to the alginate quantification in an antacid pharmaceutical formulation. Precise and reproducible analysis results were obtained, with liquid formulations injected directly without any pre-separation process.

AB - A micellar electrokinetic chromatography method was developed for the determination and quantification of sodium alginate. The alginate peak migrated in the very short time of 1.33 min and calibrated easily though the polydisperse properties of alginates. The minimum detection limit (LOD) of the method was calculated as 0.393 mg/ml. This analysis method was successfully applied to the alginate quantification in an antacid pharmaceutical formulation. Precise and reproducible analysis results were obtained, with liquid formulations injected directly without any pre-separation process.

KW - Alginate

KW - Antacid

KW - Capillary electrophoresis

KW - MEKC

UR - https://www.scopus.com/pages/publications/34247180700

U2 - 10.1016/j.jchromb.2006.12.025

DO - 10.1016/j.jchromb.2006.12.025

M3 - Article

C2 - 17224310

AN - SCOPUS:34247180700

SN - 1570-0232

VL - 850

SP - 488

EP - 492

JO - Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

JF - Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

IS - 1-2

ER -

Determination of alginate copolymer in pharmaceutical formulations by micellar electrokinetic chromatography

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Keywords

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