Cytocompatibility property evaluation of gas pressure sintered SiAlON-SiC composites with L929 fibroblast cells and Saos-2 osteoblast-like cells

Alok Kumar, Awadesh Kumar Mallik, Nurcan Calis Acikbas, Merve Yaygingol, Ferhat Kara, Hasan Mandal, Debabrata Basu, Krishanu Biswas, Bikramjit Basu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Although the oxide ceramics have widely been investigated for their biocompatibility, non-oxide ceramics, such as SiAlON and SiC are yet to be explored in detail. Lack of understanding of the biocompatibility restricts the use of these ceramics in clinical trials. It is hence, essential to carry out proper and thorough study to assess cell adhesion, cytocompatibility and cell viability on the non-oxide ceramics for the potential applications. In this perspective, the present research work reports the cytocompatibility of gas pressure sintered SiAlON monolith and SiAlON-SiC composites with varying amount of SiC, using connective tissue cells (L929) and bone cells (Saos-2). The quantification of cell viability using MTT assay reveals the non-cytotoxic response. The cell viability has been found to be cell type dependent. An attempt has been made to discuss the cytocompatibility of the developed composites in the light of SiC content and type of sinter additives.

Original languageEnglish
Pages (from-to)464-469
Number of pages6
JournalMaterials Science and Engineering C
Volume32
Issue number3
DOIs
Publication statusPublished - 1 Apr 2012
Externally publishedYes

Keywords

  • Composite
  • Cytocompatibility
  • In vitro
  • SiAlON
  • SiC

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