Controlled temperature tissue Fusion: Ho:YAG laser welding of rat intestine in vivo

Inci Cilesiz, Eric K. Chan, A. J. Welch, Sharon Thomsen

Research output: Contribution to journalConference articlepeer-review

1 Citation (Scopus)


The results of a closed loop thermal feedback controlled laser-assisted tissue welding study in vivo are reported. A series of experiments was carried out to study and compare the weld strength and healing response of sutured and laser welded rat enterotomies with and without temperature feedback control (TFC) using a cryogenically cooled Ho:YAG laser. Although assignment of animals to three groups (control sutured, laser welded with and without TFC) and four observation periods (1, 3, 7, and 21 days) was randomized, several laser welded enterotomies without TFC had complications resulting in death of the animals. Those experiments were repeated. From the failure rates encountered, it is shown that TFC improves the quality of laser-assisted enterotomy closures.

Original languageEnglish
Pages (from-to)523-534
Number of pages12
JournalProceedings of SPIE - The International Society for Optical Engineering
Publication statusPublished - 12 May 1995
Externally publishedYes
EventLasers in Surgery: Advanced Characterization, Therapeutics, and Systems V 1995 - San Jose, United States
Duration: 1 Feb 199528 Feb 1995

Bibliographical note

Publisher Copyright:
© SPIE 1995. All rights reserved.


This work was supported in part by the Department of Energy grant number DE-FGO5-91 ER 617 226 and in part by Albert and Clemmie Caster Foundation.

FundersFunder number
Albert and Clemmie Caster Foundation
U.S. Department of EnergyDE-FGO5-91 ER 617 226


    • Feedback Control
    • Ho:Yag Laser
    • Intestine
    • Quasi-Constant Temperature Control
    • S: Dosimetry
    • Temperature Feedback
    • Tissue Fusion
    • Tissue Welding.


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