Abstract
The importance of innate immunity lies not only in directly confronting pathogenic and non-pathogenic insults but also in instructing the development of an efficient adaptive immune response. The Nlrp3 inflammasome provides a platform for the activation of caspase-1 with the subsequent processing and secretion of IL-1 family members. Given the importance of IL-1 in a variety of inflammatory diseases, understanding the role of the Nlrp3 inflammasome in the initiation of innate and adaptive immune responses cannot be overstated. This review examines recent advances in inflammasome biology with an emphasis on its roles in sterile inflammation and triggering of adaptive immune responses.
Original language | English |
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Pages (from-to) | 1263-1270 |
Number of pages | 8 |
Journal | Microbes and Infection |
Volume | 14 |
Issue number | 14 |
DOIs | |
Publication status | Published - Nov 2012 |
Externally published | Yes |
Funding
NIH grants R01 AI087630 (F.S.S.), K08 AI067736 (S.L.C.), T32 AI007485 (J.R.J.), an Edward Mallinckrodt, Jr. Foundation scholarship (F.S.S.), a Merit Review Grant from the Veterans Administration IBX000167A (F.S.S.) and an Asthma and Allergy Foundation of America fellowship (S.L.C.) supported this work. The Inflammation Program is supported by resources and use of facilities at the Veterans Affairs Medical Center, Iowa City, IA. The authors have no conflicting financial interests.
Funders | Funder number |
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Veterans Administration IBX000167A | |
National Institutes of Health | K08 AI067736, T32 AI007485 |
National Institute of Allergy and Infectious Diseases | R01AI087630 |
Asthma and Allergy Foundation of America |
Keywords
- Adaptive immunity
- Inflammasome
- Innate immunity