Control of innate and adaptive immunity by the inflammasome

Ceren Ciraci; John R. Janczy; Fayyaz S. Sutterwala; Suzanne L. Cassel

doi:10.1016/j.micinf.2012.07.007

Control of innate and adaptive immunity by the inflammasome

Ceren Ciraci, John R. Janczy, Fayyaz S. Sutterwala, Suzanne L. Cassel^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

63 Citations (Scopus)

Abstract

The importance of innate immunity lies not only in directly confronting pathogenic and non-pathogenic insults but also in instructing the development of an efficient adaptive immune response. The Nlrp3 inflammasome provides a platform for the activation of caspase-1 with the subsequent processing and secretion of IL-1 family members. Given the importance of IL-1 in a variety of inflammatory diseases, understanding the role of the Nlrp3 inflammasome in the initiation of innate and adaptive immune responses cannot be overstated. This review examines recent advances in inflammasome biology with an emphasis on its roles in sterile inflammation and triggering of adaptive immune responses.

Original language	English
Pages (from-to)	1263-1270
Number of pages	8
Journal	Microbes and Infection
Volume	14
Issue number	14
DOIs	https://doi.org/10.1016/j.micinf.2012.07.007
Publication status	Published - Nov 2012
Externally published	Yes

Funding

NIH grants R01 AI087630 (F.S.S.), K08 AI067736 (S.L.C.), T32 AI007485 (J.R.J.), an Edward Mallinckrodt, Jr. Foundation scholarship (F.S.S.), a Merit Review Grant from the Veterans Administration IBX000167A (F.S.S.) and an Asthma and Allergy Foundation of America fellowship (S.L.C.) supported this work. The Inflammation Program is supported by resources and use of facilities at the Veterans Affairs Medical Center, Iowa City, IA. The authors have no conflicting financial interests.

Funders	Funder number
Veterans Administration IBX000167A
National Institutes of Health	K08 AI067736, T32 AI007485
National Institute of Allergy and Infectious Diseases	R01AI087630
Asthma and Allergy Foundation of America

Keywords

Adaptive immunity
Inflammasome
Innate immunity

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10.1016/j.micinf.2012.07.007

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Control of innate and adaptive immunity by the inflammasome

Abstract

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Keywords

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