TY - JOUR
T1 - Colloidal properties and in vitro evaluation of Hydroxy ethyl cellulose coated iron oxide particles for targeted drug delivery
AU - Bekaroğlu, Maide Gökçe
AU - İşçi, Yavuz
AU - İşçi, Sevim
N1 - Publisher Copyright:
© 2017 Elsevier B.V.
PY - 2017/9/1
Y1 - 2017/9/1
N2 - In this study, superparamagnetic iron oxide (Fe3O4) nanoparticles were prepared for the targeted drug delivery applications by controlling the colloidal properties with a cellulosic polymer that is Hydroxy ethyl cellulose (HEC). Fe3O4 particles were treated with HEC in a variable range of polymer concentration. Rheological, electrokinetic, magnetorheological and morphological properties of the dispersions were investigated to have stable and fully covered surfaces of Fe3O4 particles by coating with HEC and obtaining non-toxic biocompatible multifunctional magnetic particles. Fully coated HEC and iron-oxide particles were characterized thermally, magnetically and tested for toxicity in vitro. Then Doxorubicin hydrochloride (DOX), which is an anticancer drug widely used for cancer therapies, was loaded onto nanoparticles and their drug loading efficiency was determined. Finally, effects of DOX-loaded particles on the cancer cells were examined to report a nano drug system which can potentially open up new possibilities in the design of therapeutic agents. Results indicated that the synthesized nanoparticles in this study could be suitable to magnetically manipulated targeted delivery systems, imaging, magnetic hyperthermia treatments.
AB - In this study, superparamagnetic iron oxide (Fe3O4) nanoparticles were prepared for the targeted drug delivery applications by controlling the colloidal properties with a cellulosic polymer that is Hydroxy ethyl cellulose (HEC). Fe3O4 particles were treated with HEC in a variable range of polymer concentration. Rheological, electrokinetic, magnetorheological and morphological properties of the dispersions were investigated to have stable and fully covered surfaces of Fe3O4 particles by coating with HEC and obtaining non-toxic biocompatible multifunctional magnetic particles. Fully coated HEC and iron-oxide particles were characterized thermally, magnetically and tested for toxicity in vitro. Then Doxorubicin hydrochloride (DOX), which is an anticancer drug widely used for cancer therapies, was loaded onto nanoparticles and their drug loading efficiency was determined. Finally, effects of DOX-loaded particles on the cancer cells were examined to report a nano drug system which can potentially open up new possibilities in the design of therapeutic agents. Results indicated that the synthesized nanoparticles in this study could be suitable to magnetically manipulated targeted delivery systems, imaging, magnetic hyperthermia treatments.
KW - Cancer therapy
KW - Colloids
KW - Drug delivery systems
KW - Nanotechnology
KW - Surface modification
UR - http://www.scopus.com/inward/record.url?scp=85018318734&partnerID=8YFLogxK
U2 - 10.1016/j.msec.2017.04.030
DO - 10.1016/j.msec.2017.04.030
M3 - Article
C2 - 28576058
AN - SCOPUS:85018318734
SN - 0928-4931
VL - 78
SP - 847
EP - 853
JO - Materials Science and Engineering C
JF - Materials Science and Engineering C
ER -
