Click and Multicomponent Reactions Work Together for Polymer Chemistry

This article investigates the current combinations of click and multicomponent reactions (MCRs) to produce complex macromolecular structures through polymer–polymer conjugation or hetero-functionalization of polymers. The click and MCRs display similar features covering the equimolarity, fast time scale, high yields, stable compounds, modular, orthogonal and single reaction trajectory. Of classical click reactions, CuAAC, Diels–Alder, thiol-ene (-yne), and nucleophilic substitution on perfluoroaryl groups reactions are combined with MCRs, namely, Passerini, Ugi, or Biginelli reactions. It should be noted that these combinations can afford the target polymer structures, which are not attainable by employing one of these reactions alone.