Chemistry of Protein-Phenolic Interactions Toward the Microbiota and Microbial Infections

Hilal Yilmaz, Busra Gultekin Subasi, Hasan Ufuk Celebioglu, Tugba Ozdal, Esra Capanoglu*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

16 Citations (Scopus)

Abstract

Along with health concerns, interest in plants as food and bioactive phytochemical sources has been increased in the last few decades. Phytochemicals as secondary plant metabolites have been the subject of many studies in different fields. Breakthrough for research interest on this topic is re-juvenilized with rising relevance in this global pandemics' era. The recent COVID-19 pandemic attracted the attention of people to viral infections and molecular mechanisms behind these infections. Thus, the core of the present review is the interaction of plant phytochemicals with proteins as these interactions can affect the functions of co-existing proteins, especially focusing on microbial proteins. To the best of our knowledge, there is no work covering the protein-phenolic interactions based on their effects on microbiota and microbial infections. The present review collects and defines the recent data, representing the interactions of phenolic compounds -primarily flavonoids and phenolic acids- with various proteins and explores how these molecular-level interactions account for the human health directly and/or indirectly, such as increased antioxidant properties and antimicrobial capabilities. Furthermore, it provides an insight about the further biological activities of interacted protein-phenolic structure from an antiviral activity perspective. The research on the protein-phenolic interaction mechanisms is of great value for guiding how to take advantage of synergistic effects of proteins and polyphenolics for future medical and nutritive approaches and related technologies.

Original languageEnglish
Article number914118
JournalFrontiers in Nutrition
Volume9
DOIs
Publication statusPublished - 1 Jul 2022

Bibliographical note

Publisher Copyright:
Copyright © 2022 Yilmaz, Gultekin Subasi, Celebioglu, Ozdal and Capanoglu.

Keywords

  • antioxidant activity
  • antiviral
  • food phenolics
  • microbial protein (MP)
  • phytochemicals
  • protein-phenolic interaction

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