CFD MODELS FOR ANEURYSM ANALYSES AND THEIR USE IN IDENTIFYING THROMBOSIS FORMATION AND RISK ASSESSMENT

H. Pahlavani, I. B. Ozdemir*, D. Yildirim

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

In this paper, the blood transport has been investigated using the single- and the two-phase methods. In the two-phase Euler-Euler approach, the blood is represented by two interpenetrating continua where the dispersed red blood cells (RBCs) of non-Newtonian characteristics are suspended in the continuous Newtonian plasma. The results of the two-phase model, where the RBC's phase is assumed to be Carreau-Yasuda fluid, are validated against the experimental data. Furthermore, comparative analyses were performed in two patient-specific aneurysms, which indicated that for a given pulsatile flow rate, the two-phase blood approach is vitally advantageous over the single-phase assumption, and revealed a deeper inflow penetration, more complex flow structures and denser flow diversion zones in the aneurysm sac. It was obvious that the high OSI values calculated by the two-phase model covered much wider regions than the values predicted by the single-phase model. It was equally crucial that these regions coincided with the TAWSS values lower than the threshold that the single-phase approach can predict. Apparently, the single-phase model failed to spot sites of high rupture risk. The results were further exploited to identify the RBCs aggregation regions as, for example, the concave structures and narrow paths in the saccular aneurysms, for their possible use as the precursors of the thrombus formation.

Original languageEnglish
Article number2250061
JournalJournal of Mechanics in Medicine and Biology
Volume22
Issue number7
DOIs
Publication statusPublished - 1 Sept 2022

Bibliographical note

Publisher Copyright:
© 2022 World Scientific Publishing Company.

Keywords

  • Euler-Euler approach
  • non-Newtonian viscosity
  • Two-phase blood flow

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