Cerium doped magnetite nanoparticles for highly sensitive detection of metronidazole via chemiluminescence assay

Yasin Orooji; Mahsa Haddad Irani-nezhad; Ramin Hassandoost; Alireza Khataee; Shima Rahim Pouran; Sang Woo Joo

doi:10.1016/j.saa.2020.118272

Cerium doped magnetite nanoparticles for highly sensitive detection of metronidazole via chemiluminescence assay

Yasin Orooji, Mahsa Haddad Irani-nezhad, Ramin Hassandoost, Alireza Khataee^*, Shima Rahim Pouran, Sang Woo Joo

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

157 Citations (Scopus)

Abstract

Cerium doped magnetite nanoparticle (CDM) was synthesized via a co-precipitation method and used as the co-reactant of luminol-K₃Fe(CN)₆ chemiluminescent system. The physical-chemical features of CDM were studied by XPS, XRD, HRTEM, FESEM, VSM, BET, and FTIR analyses. This simple and highly sensitive nanoprobe enabled the determination of minor concentrations of metronidazole (MNZ). Owing to the quenching efficacy of MNZ in the studied chemiluminescence system, a linear range of 3.47 × 10⁻⁶-9.37 × 10⁻⁵ mol/L was obtained with a limit of detection of 3.91 × 10⁻⁷ mol/L. This biosensor was used for MNZ detection in human serum samples, which was highly efficient. The outcomes of this study give credit to the proposed biosensor to be applied for detection of MNZ in biological samples.

Original language	English
Article number	118272
Journal	Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
Volume	234
DOIs	https://doi.org/10.1016/j.saa.2020.118272
Publication status	Published - 15 Jun 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2018 Elsevier B.V.

Keywords

Antibiotics detection
Chemiluminescence
Human plasma
Magnetic sensor
Metronidazole

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title = "Cerium doped magnetite nanoparticles for highly sensitive detection of metronidazole via chemiluminescence assay",

abstract = "Cerium doped magnetite nanoparticle (CDM) was synthesized via a co-precipitation method and used as the co-reactant of luminol-K3Fe(CN)6 chemiluminescent system. The physical-chemical features of CDM were studied by XPS, XRD, HRTEM, FESEM, VSM, BET, and FTIR analyses. This simple and highly sensitive nanoprobe enabled the determination of minor concentrations of metronidazole (MNZ). Owing to the quenching efficacy of MNZ in the studied chemiluminescence system, a linear range of 3.47 × 10−6-9.37 × 10−5 mol/L was obtained with a limit of detection of 3.91 × 10−7 mol/L. This biosensor was used for MNZ detection in human serum samples, which was highly efficient. The outcomes of this study give credit to the proposed biosensor to be applied for detection of MNZ in biological samples.",

keywords = "Antibiotics detection, Chemiluminescence, Human plasma, Magnetic sensor, Metronidazole",

author = "Yasin Orooji and {Haddad Irani-nezhad}, Mahsa and Ramin Hassandoost and Alireza Khataee and {Rahim Pouran}, Shima and Joo, {Sang Woo}",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier B.V.",

year = "2020",

month = jun,

day = "15",

doi = "10.1016/j.saa.2020.118272",

language = "English",

volume = "234",

journal = "Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy",

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TY - JOUR

T1 - Cerium doped magnetite nanoparticles for highly sensitive detection of metronidazole via chemiluminescence assay

AU - Orooji, Yasin

AU - Haddad Irani-nezhad, Mahsa

AU - Hassandoost, Ramin

AU - Khataee, Alireza

AU - Rahim Pouran, Shima

AU - Joo, Sang Woo

PY - 2020/6/15

Y1 - 2020/6/15

N2 - Cerium doped magnetite nanoparticle (CDM) was synthesized via a co-precipitation method and used as the co-reactant of luminol-K3Fe(CN)6 chemiluminescent system. The physical-chemical features of CDM were studied by XPS, XRD, HRTEM, FESEM, VSM, BET, and FTIR analyses. This simple and highly sensitive nanoprobe enabled the determination of minor concentrations of metronidazole (MNZ). Owing to the quenching efficacy of MNZ in the studied chemiluminescence system, a linear range of 3.47 × 10−6-9.37 × 10−5 mol/L was obtained with a limit of detection of 3.91 × 10−7 mol/L. This biosensor was used for MNZ detection in human serum samples, which was highly efficient. The outcomes of this study give credit to the proposed biosensor to be applied for detection of MNZ in biological samples.

AB - Cerium doped magnetite nanoparticle (CDM) was synthesized via a co-precipitation method and used as the co-reactant of luminol-K3Fe(CN)6 chemiluminescent system. The physical-chemical features of CDM were studied by XPS, XRD, HRTEM, FESEM, VSM, BET, and FTIR analyses. This simple and highly sensitive nanoprobe enabled the determination of minor concentrations of metronidazole (MNZ). Owing to the quenching efficacy of MNZ in the studied chemiluminescence system, a linear range of 3.47 × 10−6-9.37 × 10−5 mol/L was obtained with a limit of detection of 3.91 × 10−7 mol/L. This biosensor was used for MNZ detection in human serum samples, which was highly efficient. The outcomes of this study give credit to the proposed biosensor to be applied for detection of MNZ in biological samples.

KW - Antibiotics detection

KW - Chemiluminescence

KW - Human plasma

KW - Magnetic sensor

KW - Metronidazole

UR - http://www.scopus.com/inward/record.url?scp=85082605226&partnerID=8YFLogxK

U2 - 10.1016/j.saa.2020.118272

DO - 10.1016/j.saa.2020.118272

M3 - Article

C2 - 32229321

AN - SCOPUS:85082605226

SN - 1386-1425

VL - 234

JO - Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy

JF - Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy

M1 - 118272

ER -

Cerium doped magnetite nanoparticles for highly sensitive detection of metronidazole via chemiluminescence assay

Abstract

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Keywords

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